噌啉支架的多种生物活性概述

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC
Mohammad Asif, Mamdouh Allahyani, Abdulelah Aljuaid, Mazen M. Almehmadi, Ahad Alsaiari, Abdulaziz Alsharif
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引用次数: 0

摘要

:噌啉核是一个双环,是喹诺酮或异喹啉的同素异形前体。噌啉类似物是芳香杂环化合物,具有多种治疗活性,如抗菌、镇痛、消炎、抗结核、抗疟、抗惊厥、抗氧化、抗癌、降压、抗焦虑等。这种杂环核在药物化学中备受关注,被用作各种化合物的结构亚基,具有诱人的药物和化学特性。在这篇综述中,我们将重点讨论具有各种取代结构的噌啉类似物的生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Diverse Biological Activities of Cinnoline Scaffold
: The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural subunit in various compounds with attractive medicinal and chemical properties. In this review, we focus on the biological activities of cinnoline analogs with various substitutions.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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