慢性阻塞性肺病与精神障碍风险的关系:双样本孟德尔随机研究

IF 2.8 3区 医学 Q1 Medicine
Qinxia Zhang, Haifu Zhang, Qinxing Xu
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引用次数: 0

摘要

背景:慢性阻塞性肺疾病(COPD)是一种常见的呼吸系统疾病,通常伴有合并症。尽管在过去几年中取得了重大的科学进步,但慢性阻塞性肺病与精神疾病之间的潜在关系仍是一个争论的话题:我们从全基因组关联研究(GWAS)目录中检索了慢性阻塞性肺病的数据,并从精神疾病基因组学联盟(Psychiatric Genomics Consortium)中检索了阿尔茨海默病、精神分裂症、恐慌症、注意缺陷多动障碍(ADHD)、双相情感障碍、重度抑郁障碍、多重残疾、强迫症、创伤后应激障碍和精神分裂症等精神疾病的数据。我们采用了双样本孟德尔随机化(MR)方法来探讨慢性阻塞性肺病与精神疾病之间的关联,并根据吸烟史进行了亚组分析:我们的双样本 MR 分析显示,慢性阻塞性肺病与常见精神疾病的发生之间没有因果关系。基于吸烟史的亚组分析显示,从未吸烟的慢性阻塞性肺病患者与精神疾病的发生之间没有因果关系。然而,曾经吸烟的慢性阻塞性肺病患者罹患多动症的风险显著增加(OR:2.303,95% CI:1.558- 3.403,P = 0.001),而罹患阿尔茨海默病的风险则略有降低(OR:0.994,95% CI:0.988- 0.999,P = 0.034):结论:有吸烟史的慢性阻塞性肺病患者患多动症的风险较高,但患阿尔茨海默病的风险可能会略有降低。相反,在从不吸烟的慢性阻塞性肺病患者中,没有观察到慢性阻塞性肺病与精神障碍之间的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Chronic Obstructive Pulmonary Disease with Risk of Psychiatric Disorders: A Two-Sample Mendelian Randomization Study
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder often accompanied by comorbidities. Although the past few years have witnessed significant scientific progress, the potential relationship between COPD and mental illness remains a subject of debate.
Materials and Methods: We retrieved COPD data from the genome-wide association studies (GWAS) directory and data on mental illnesses, including Alzheimer’s disease, schizophrenia, panic disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, multiple disabilities, obsessive-compulsive disorder, post-traumatic stress disorder, and schizophrenia, from the Psychiatric Genomics Consortium. A two-sample Mendelian randomization (MR) approach was applied to explore the association between COPD and mental illnesses, with subgroup analyses based on smoking history.
Results: Our two-sample MR analysis revealed no causal link between overall COPD and the development of common psychiatric disorders. Subgroup analyses based on smoking history showed no causal association between never-smokers with COPD and the occurrence of psychiatric disorders. However, ever-smokers with COPD were associated with a significantly increased risk of ADHD (OR: 2.303, 95% CI: 1.558– 3.403, P = 0.001) and a modestly reduced risk of Alzheimer’s disease (OR: 0.994, 95% CI: 0.988– 0.999, P = 0.034).
Conclusion: COPD patients with a history of smoking face a higher risk of developing ADHD but may experience a slight reduction in the risk of Alzheimer’s disease. Conversely, there was no observed causal association between COPD and psychiatric disorders among patients who never smoked.

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来源期刊
CiteScore
5.10
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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