血浆纤维蛋白原水平对 2 型糖尿病患者中风风险的影响:系统回顾

Nicoline Daugaard, Else-Marie Bladbjerg, Moniek P M de Maat, Anna-Marie Bloch Münster
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引用次数: 0

摘要

目的 在本系统综述中,我们评估了有关 2 型糖尿病(T2D)患者纤维蛋白原水平与中风之间关系的文献。方法 在 MEDLINE 和 Ovid 中检索有关人类纤维蛋白原、中风和 T2D 之间关系的英文报告。检索于 2023 年 5 月 4 日完成。如果经计算机断层扫描或磁共振成像证实有脑卒中的≥18 岁 T2D 患者,测量了血浆纤维蛋白原,并报道了纤维蛋白原与 T2D 患者脑卒中之间的关系,则符合研究条件。报告筛选和数据提取由两位作者独立完成,研究质量按预先设定的问题进行评估。结果 共纳入了五项不同设计的研究。三项研究报告称,与未发生中风的 T2D 患者相比,中风 T2D 患者的纤维蛋白原水平明显升高。两项研究未观察到纤维蛋白原水平与中风风险之间存在明显关联。结论 在 T2D 患者的纤维蛋白原水平与中风风险之间未观察到一致的关联。由于研究设计不同、样本量少、研究参与者定义不清,因此需要更大规模、定义更明确的研究来阐明纤维蛋白原作为 T2D 患者卒中风险标志物的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Plasma Fibrinogen Levels on the Risk of Stroke in Patients with Type 2 Diabetes: A Systematic Review.

Aims  In this systematic review, we assessed the literature on the association between fibrinogen levels and stroke in patients with type 2 diabetes (T2D). Methods  MEDLINE and Ovid searches of English reports were performed on the relation between fibrinogen, stroke, and T2D in humans. The search was completed on May 4, 2023. Studies were eligible when T2D patients ≥18 years had stroke confirmed by computed tomography or magnetic resonance imaging, plasma fibrinogen was measured, and a relation between fibrinogen and stroke in T2D patients was reported. Screening of reports and extraction of data were done independently by two authors, and study quality was assessed by predefined issues. Results  Five studies of different designs were included. Three studies reported on significantly increased fibrinogen levels in T2D patients with stroke compared with T2D patients without stroke. Two studies did not observe a significant association between fibrinogen levels and stroke risk. Conclusion  No consistent association was observed between fibrinogen levels and risk of stroke in T2D patients. Due to differences in study design, low sample size, and poorly defined study participants, larger and better-defined studies are needed to elucidate the role of fibrinogen as a stroke risk marker in T2D patients.

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