近亲繁殖抑制与比利时蓝肉牛最近的同源后裔区段有关。

IF 3.6 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Maulana Mughitz Naji, José Luis Gualdrón Duarte, Natalia Soledad Forneris, Tom Druet
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引用次数: 0

摘要

背景:牛群的近亲繁殖水平普遍较高,可能导致近亲繁殖抑制(ID)。在此,我们用近交系数 F 的不同估计值来研究近交抑郁,评估它们对所用等位基因频率(始祖等位基因频率与样本等位基因频率)的敏感性,并比较近期近交和远期近交的影响:我们使用了 14205 头比利时蓝肉牛基因分型奶牛的数据,这些数据针对 11 个线性分类性状进行了表型分析。我们根据血统信息(FPED)、结合配子间的相关性(FUNI)、基因组关系矩阵(FGRM)、过高同源性(FHET)或后代同源性(HBD)片段(FHBD)计算了F的估计值:结果:FUNI 和 FGRM 对使用过的等位基因频率很敏感,而 FHET 和 FHBD 则更稳健。我们在与身高和体长相关的四个性状中检测到了明显的 ID,其中 FHBD 和 FUNI 的关联性最强。然后,我们利用 HBD 片段在不同年龄相关类别中的分类(HBD 片段的长度与共同祖先的世代数成反比),确定最近的 HBD 类别(共同祖先大约出现在 15 代之前)比更古老的 HBD 类别具有更强的 ID。我们还进行了其他分析,以检验这些观察结果是否可能是由于古代 HBD 类的变异水平较低,或者是由于识别这些较短片段的精确度较低:总之,我们的研究结果表明,突变负荷会随着单倍型年龄的增长而降低,交配计划应主要考虑近期近亲繁殖的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inbreeding depression is associated with recent homozygous-by-descent segments in Belgian Blue beef cattle.

Background: Cattle populations harbor generally high inbreeding levels that can lead to inbreeding depression (ID). Here, we study ID with different estimators of the inbreeding coefficient F, evaluate their sensitivity to used allele frequencies (founder versus sample allele frequencies), and compare effects from recent and ancient inbreeding.

Methods: We used data from 14,205 Belgian Blue beef cattle genotyped cows that were phenotyped for 11 linear classification traits. We computed estimators of F based on the pedigree information (FPED), on the correlation between uniting gametes (FUNI), on the genomic relationship matrix (FGRM), on excess homozygosity (FHET), or on homozygous-by-descent (HBD) segments (FHBD).

Results: FUNI and FGRM were sensitive to used allele frequencies, whereas FHET and FHBD were more robust. We detected significant ID for four traits related to height and length; FHBD and FUNI presenting the strongest associations. Then, we took advantage of the classification of HBD segments in different age-related classes (the length of an HBD segment being inversely related to the number of generations to the common ancestors) to determine that recent HBD classes (common ancestors present approximately up to 15 generations in the past) presented stronger ID than more ancient HBD classes. We performed additional analyses to check whether these observations could result from a lower level of variation in ancient HBD classes, or from a reduced precision to identify these shorter segments.

Conclusions: Overall, our results suggest that mutational load decreases with haplotype age, and that mating plans should consider mainly the levels of recent inbreeding.

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来源期刊
Genetics Selection Evolution
Genetics Selection Evolution 生物-奶制品与动物科学
CiteScore
6.50
自引率
9.80%
发文量
74
审稿时长
1 months
期刊介绍: Genetics Selection Evolution invites basic, applied and methodological content that will aid the current understanding and the utilization of genetic variability in domestic animal species. Although the focus is on domestic animal species, research on other species is invited if it contributes to the understanding of the use of genetic variability in domestic animals. Genetics Selection Evolution publishes results from all levels of study, from the gene to the quantitative trait, from the individual to the population, the breed or the species. Contributions concerning both the biological approach, from molecular genetics to quantitative genetics, as well as the mathematical approach, from population genetics to statistics, are welcome. Specific areas of interest include but are not limited to: gene and QTL identification, mapping and characterization, analysis of new phenotypes, high-throughput SNP data analysis, functional genomics, cytogenetics, genetic diversity of populations and breeds, genetic evaluation, applied and experimental selection, genomic selection, selection efficiency, and statistical methodology for the genetic analysis of phenotypes with quantitative and mixed inheritance.
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