多粘菌素的结构与功能研究。多粘菌素M在水中构象的1H NMR分析[j]。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-10-01

V V Okhanov, P V Dubovskiĭ, M N Trakhanova, D I Bairamashvili, A A Zinchenko

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引用次数: 0

摘要

采用一、二维(COSY, COSY-45, RELAY)氢核磁共振波谱技术研究了多肽抗生素多粘菌素M在水中的空间结构。信号光谱参数分析显示，在分子的环状部分存在两个分子内氢键，其结构类似于多粘菌素B。然而，多粘菌素M结构中两个β -转的构型与早前在多粘菌素B结构中检测到的β -转的构型不同。

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[Structural and functional research on polymyxins. 1H NMR analysis of the conformation of polymyxin M in water].

Spatial structure of polypeptide antibiotic polymyxin M in water was studied by one-and two-dimensional (COSY, COSY-45, RELAY) H NMR spectroscopy. Analysis of the signal spectral parameters revealed two intramolecular hydrogen bonds in the cyclic part of the molecule which was analogous to the structure of polymyxin B. However, configuration of both the beta-turns in the polymyxin M structure differed from that of the detected earlier beta-turns in the structure of polymyxin B.

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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