调节酵素刺激白三烯释放的膳食不饱和脂肪酸

J. Bruce German, Belur Lokesh, J.E. Kinsella
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引用次数: 24

摘要

在炎症模型(受刺激的小鼠腹膜)中产生的白三烯的数量受到饮食操纵组织花生四烯酸(直接白三烯(LT)前体)的影响。以橄榄油为不饱和脂肪酸膳食来源的小鼠腹腔内合成50 ng LTE4(注射zymosan后)。饲喂玉米油的动物在酶聚糖刺激下,白三烯的生物合成显著增强。喂食富含n-3脂肪酸的鲱鱼油的老鼠产生的白三烯E4比喂食橄榄油的老鼠少50%。结果表明,白三烯的产生受到日粮中多不饱和脂肪酸类型的影响,白三烯是炎症反应的有效介质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modulation of zymosan stimulated leukotriene release by dietary unsaturated fatty acids

The quantity of leukotrienes produced in an inflammation model, the stimulated mouse peritoneum, was affected by dietary manipulation of tissue arachidonic acid, the immediate leukotriene (LT) precursor. Fifty ng of LTE4 was synthesized (after injection of zymosan) by the peritoneal cavity of mice maintained on olive oil as a dietary source of unsaturated fatty acids . Animals maintained on corn oil, exhibited significantly enhanced leukotriene biosynthesis upon stimulation by zymosan. Mice fed menhaden oil, a fat source rich in n-3 fatty acids produced 50% less leukotriene E4 than animals fed olive oil. The results indicated that production of leukotrienes, potent mediators of inflammatory reactions,are affected by the type of polyunsaturated fatty acids in the diet.

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