Semaphorin 4 类亚族蛋白在实体瘤中的表达模式和发病机制。

IF 2 4区 医学 Q3 ONCOLOGY
Neoplasma Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI:10.4149/neo_2024_230907N475
Dongjun Jiang, Xiaoli Chen, Xiuting Li, Jian Qiu, Peng Xu, Xuezhi Li
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引用次数: 0

摘要

半合成蛋白最初被描述为神经系统发育的调节因子。此外,半角蛋白家族成员在实体瘤的生长、转移和血管生成中也发挥着重要作用。与其他半合成蛋白亚类不同,第4类半合成蛋白既有膜结合型,也有活性可溶型。体液(血液和唾液)中的可溶性第 4 类半合成蛋白可作为潜在的生物标记物,用于特定癌症的早期诊断和预后预测。4 类半合成蛋白还能以细胞膜结合的形式在癌细胞中传递信号,从而调节癌症的发展。在实体瘤中,4类半合成蛋白可以活性可溶形式作为配体,通过自分泌和旁分泌激活肿瘤微环境中癌细胞或内皮细胞的信号转导,从而调节癌症的进展。靶向第 4 类半合成蛋白可能是特异性癌症治疗的一种新策略。然而,第 4 类拟杆菌素在实体瘤中的表达及其响应的发病机制仍存在争议。因此,本综述总结了第 4 类 semaphorin 成员在不同类型实体瘤中的特异性表达调控以及癌症进展的相关机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression patterns and pathogenesis of Semaphorin class 4 subfamily proteins in solid tumors.

Semaphorins are originally described as regulators of nervous system development. Besides, members of the semaphorin family play important roles in the growth, metastasis, and angiogenesis of solid tumors. In contrast to the other semaphorin subclasses, semaphorin class 4 has both membrane-bound and active soluble forms. Soluble class 4 semaphorins in body fluids (blood and saliva) may serve as potential biomarkers for early diagnosis and prognosis prediction of specific cancers. The class 4 semaphorins also transduce signal in cancer cells in a cell membrane-bound form, thereby regulating cancer progression. In solid tumors, class 4 semaphorins can act as ligands in active soluble forms, regulating cancer progression via autocrine and paracrine to activate signal transduction in cancer cells or endothelial cells in the tumor microenvironment. Targeting class 4 semaphorins may be a novel strategy for specific cancer therapy. However, the expression of class 4 semaphorins in solid tumors and the responsive pathogenesis are still controversial. Therefore, this review summarizes the specific expression regulation of class 4 semaphorin members in different types of solid tumors and the mechanisms involved in cancer progression.

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来源期刊
Neoplasma
Neoplasma 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
238
审稿时长
3 months
期刊介绍: The journal Neoplasma publishes articles on experimental and clinical oncology and cancer epidemiology.
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