食品香料甲基苯甲酸甲酯通过抑制 cAMP 来下调黑色素生成酶，从而减轻皮肤色素沉着。

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Biomolecules & Therapeutics Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI:10.4062/biomolther.2023.103

Heui-Jin Park, Kyuri Kim, Eun-Young Lee, Prima F Hillman, Sang-Jip Nam, Kyung-Min Lim

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引用次数: 0

摘要

蒽酸甲酯（MA）是一种用于食品调味的植物香料，在抗色素化妆品中的应用潜力尚待开发。在人类黑色素瘤细胞（MNT-1）和人类角质形成细胞系（HaCaT）的共培养系统中，MA可剂量依赖性地降低黑色素含量，但不影响细胞活力，抑制树突延伸和黑色素小体转移，并下调黑色素形成基因，包括酪氨酸酶、酪氨酸酶相关蛋白1和2（TRP-1和TRP-2）。此外，MA还能减少环磷酸腺苷（cAMP）的产生，并在MelanodermTM中表现出显著的抗色素沉着作用。这些结果表明，MA 是一种很有前途的抗色素沉着剂，可以替代或补充现有的抗色素沉着化妆品。

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Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression.

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

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来源期刊

Biomolecules & Therapeutics 医学-药学

CiteScore

6.60

自引率

8.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. It was launched in 1993 as "The Journal of Applied Pharmacology (ISSN 1225-6110)", and renamed "Biomolecules & Therapeutics" (Biomol Ther: abbreviated form) in 2008 (Volume 16, No. 1). It is published bimonthly in January, March, May, July, September and November. All manuscripts should be creative, informative, and contribute to the development of new drugs. Articles in the following categories are published: review articles and research articles.