步行与骨关节炎有关吗？双样本孟德尔随机分析

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-01-31 DOI:10.2147/cia.s442259

Jiankang Xu, Longyao Zhang, Ping Wang, Chao Zhang, Shuqing Ji

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引用次数: 0

摘要

目的：骨关节炎（OA）是人类主要致残疾病之一。相关研究表明，步行与 OA 之间存在潜在的相关性。然而，目前仍缺乏遗传学证据支持步行与 OA 之间的相关性。因此，本研究旨在从遗传学层面探讨步行与 OA 之间的关系：方法：采用公开的全基因组关联研究（GWAS）数据，以逆方差加权（IVW，随机效应模型）为主要分析方法，以MR-Egger、加权中位数、简单模式和加权模式为辅助分析方法。此外，还进行了 Cochran's Q 检验、pleiotropy 检验和 MR-Egger 截距检验，以检验结果的异质性和pleiotropy：在MR分析中，IVW结果显示过去4周的体育锻炼类型之间存在负相关：在 MR 分析中，IVW 结果显示最近 4 周的体力活动类型之间存在负相关关系：快乐步行（不作为交通工具）和 OA（KOA 或 HOA）（几率比（OR）= 0.3224，95% 置信区间（CI）：0.1261 至 0.8243），差异具有统计学意义（P = 0.0181）。此外，IVW 结果还显示，过去 4 周的体育锻炼类型之间存在负相关：为娱乐而步行（不作为交通工具）与 KOA 之间存在负相关（OR = 0.1396，95% CI：0.0484 至 0.4026），差异具有统计学意义（P = 0.0003）。然而，IVW 的结果并没有显示出过去 4 周的体力活动类型有任何统计学意义：结论：从遗传学研究来看，最近 4 周的体育锻炼类型包括关键词：骨关节炎；步行；孟德尔随机化

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Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis

Objective: Osteoarthritis (OA) is one of the major disabling human diseases. The related studies indicate a potential correlation between walking and OA. However, there is still a lack of evidence in genetics to support the correlation between walking and OA. Therefore, this study aimed to explore the relationship between walking and OA at the genetic level.
Methods: The publicly available Genome Wide Association Study (GWAS) data were used, with inverse variance weighting (IVW, the random-effects model) as the main analysis method, whereas MR-Egger, Weighted median, Simple mode, and Weighted mode as the secondary analysis methods. In addition, Cochran’s Q test, pleiotropy test, and MR-Egger intercept test were conducted to examine the heterogeneity and pleiotropy of the outcome.
Results: In the MR analysis, IVW results showed a negative correlation between types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and OA (KOA or HOA) (odds ratio (OR) = 0.3224, 95% confidence interval (CI): 0.1261 to 0.8243), and the difference was of statistical significance (P = 0.0181). Moreover, IVW results also revealed a negative correlation between types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and KOA (OR = 0.1396, 95% CI: 0.0484 to 0.4026), and the difference was statistically significant (P = 0.0003). However, IVW results did not demonstrate any statistical significance types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and HOA (OR = 1.2075, 95% CI: 0.1978 to 7.3727, P = 0.8381).
Conclusion: From genetic studies, types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) is negatively correlated with knee osteoarthritis (KOA), but there is no clear evidence supporting its correlation with hip osteoarthritis (HOA).

Keywords: osteoarthritis, walking, Mendelian randomization

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.