忧郁抑郁症伴有血清中神经生长因子水平的升高

IF 0.5 4区医学 Q4 NEUROSCIENCES

Neurochemical Journal Pub Date : 2024-01-30 DOI:10.1134/s1819712423040232

M. G. Uzbekov, S. N. Shikhov, V. V. Krjukov, V. V. Brilliantova, V. N. Krasnov

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引用次数: 0

摘要

摘要--研究的目的是了解忧郁抑郁症患者血清中神经生长因子（NGF）的水平。研究对象包括 23 名患者。入院时，在治疗开始前，患者血清中的神经生长因子水平（278.28 pg/mL）明显高于对照组（239.51 ± 22.15）（p <0.05）。我们认为，忧郁型抑郁症患者血清中的 NGF 水平升高可能与 BBB 功能受损及其对神经刺激因子的通透性增加有关。

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Melancholic Depression Is Accompanied by Increased Level of Nerve Growth Factor in Blood Serum

Abstract—The aim of the work was to study the level of nerve growth factor (NGF) in the serum of patients with melancholic depression. The examined group consisted of 23 patients. Upon admission to the clinic, before therapy began, the patients showed a significantly higher (278.28 pg/mL) level of NGF in the serum compared with control (239.51 ± 22.15) (p < 0.05). We believe that the increased level of NGF in serum in patients with melancholic depression may be associated with impaired functioning of the BBB and an increase in its permeability for neurotropic factor.

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.