非特异性炎症在糖尿病多发性神经病变发展过程中的作用

IF 0.5 4区 医学 Q4 NEUROSCIENCES
L. A. Shchepankevich, M. A. Pervuninskaya
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引用次数: 0

摘要

摘要-- 糖尿病周围神经病变(DPN)是糖尿病最常见的并发症,与严重的发病率和死亡率相关。导致 DPN 发生的病理生理机制尚未得到充分研究,目前仍存在争议。目前,人们正在讨论其免疫介导的发病机制。本研究旨在估算并发DPN的2型糖尿病(DM2)患者血清中TNF-α的含量,并评估该因子在DPN发生和发展过程中的重要性。这项公开比较研究有 83 名不同病程的 DM2 患者参加。在有DPN临床表现和长期DM2病程的患者(第2组)中,TNF-α的水平明显高于DM2和DPN病程少于2年的患者。与对照组相比,两组DM2和DPN患者的TNF-α水平都较高。我们的数据表明,随着DM2病程的延长,免疫介导的过程会变得更加严重,并对周围神经纤维的功能产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Nonspecific Inflammation in the Development of Diabetic Polyneuropathy

Abstract Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is associated with significant morbidity and mortality. The pathophysiological mechanisms leading to the development of DPN have not been fully studied and are still debatable. Currently, immune-mediated mechanisms of its development are being discussed. The aim of this study was to estimate the content of TNF-α in the blood serum of patients with diabetes mellitus type 2 (DM2) complicated by DPN and to assess the significance of this factor in the development and progression of DPN. An open comparative study was conducted with the participation of 83 patients with DM2 of different duration. In patients with clinical manifestations of DPN and long-term course of DM2 (group 2), the level of TNF-α was significantly higher compared to patients with DM2 and duration of DPN less than 2 years. Both studied groups of patients with DM2 and DPN had a higher level of TNF-α in comparison with the control group. Our data indicate a more aggressive immune-mediated process that develops with a longer duration of DM2 and makes a negative contribution to the functioning of the peripheral nerve fiber.

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来源期刊
Neurochemical Journal
Neurochemical Journal 医学-神经科学
自引率
20.00%
发文量
40
审稿时长
>12 weeks
期刊介绍: Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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