创伤性脑损伤引发的脑水肿。

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-05-01 Epub Date: 2024-01-29 DOI:10.1016/j.tips.2024.01.005

Per Kristian Eide, Geir Ringstad

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引用次数: 0

摘要

创伤性脑损伤（TBI）的后果受到脑水肿的显著影响。Hussain 等人最近的一份报告揭示了一种独特的脑水肿形式，即甘油滞留性脑水肿，它源于去甲肾上腺素能激活引起的甘油和淋巴引流受损。因此，泛去甲肾上腺素能抑制可能成为治疗创伤性脑损伤相关水肿的创新疗法，对传统治疗方法提出挑战。

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Glymphatic-stagnated edema induced by traumatic brain injury.

Traumatic brain injury (TBI) outcomes are notably affected by brain edema. A recent report by Hussain et al. unveils a unique form, glymphatic-stagnated brain edema, that stems from impaired glymphatic and lymphatic drainage induced by noradrenergic activation. Consequently, pan-noradrenergic inhibition may emerge as an innovative treatment for TBI-related edema, challenging traditional therapeutic approaches.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.