Diversity of Secondary Metabolites from Fungi of the Ascomycete Genus Tolypocladium

Fungi in the genus of Tolypocladium are often discovered as endophytes, soil inhabitants, and insect pathogens. Many biologically active secondary metabolites have been discovered from them in the past half-century, including medicinally important oligopeptide cyclosporine A, and other compounds like terpenes, polyketides, polyketide-non-ribosomal peptides. This review has summarized the chemistry and pharmacology of natural products discovered from Tolypocladium genus fungi, to provide a full record of all Tolypocladium secondary metabolites.