评估一种多草药配方的体外抗氧化和抗糖尿病活性

IF 0.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Ramen Kalita, Bipul Nath, Dipankar Saha
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引用次数: 0

摘要

近年来,新陈代谢疾病,尤其是糖尿病的识别、管理和研究有了重大进展。除了现有的合成药物外,目前的研究重点是从天然资源中开发用于治疗糖尿病的替代药物。研究目的通过体外模型研究多草药配方(PHF)的抗氧化和抗糖尿病功效。方法:对多草药配方进行筛选:筛选多草药配方中的植物化学成分。还分析了配方中的总酚和类黄酮含量。 计算配方(PHF)的体外抗氧化和抗糖尿病活性。结果:多草本配方中含有酚类、黄酮类、甾体和皂苷。在 DPPH 自由基清除试验中,PHF4 的 IC50 值为 42.70µg/ml 。 酚类(172.6±0.68 毫克/克)和黄酮类化合物(137.3±0.91 毫克/克)含量较高,淀粉酶和葡萄糖苷酶的 IC50 值分别为 422.50 微克/毫升和 438.71 微克/毫升。结论结果表明,多草药配方(PHF4)具有显著的抗氧化活性,并对α-淀粉酶和α-葡萄糖苷酶有很强的抑制作用。不过,为了进一步验证上述研究结果,将利用动物模型对多草药配方进行体内抗糖尿病研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of In vitro Antioxidant and Antidiabetic activity of a Polyherbal formulation
Recent years have seen significant improvements in the identification, management, and study of metabolic illnesses, particularly diabetes. In addition to the present synthetic medicines, current research is focused on developing an alternate source of medication from natural resources for managing diabetes. Objective: To investigate the antioxidant and antidiabetic efficacy of a poly-herbal formulation (PHF) by in vitro models. Methods: The Polyherbal formulation was screened for the presence of phytochemical constituents. The total phenolic and flavonoids content of the formulation was also analysed.  The in vitro antioxidant and antidiabetic activity of the formulation (PHF) were calculated. Results: The Polyherbal formulation showed presence of phenols, flavonoids, steroids, and saponins. The IC50 value of PHF4 was found to be 42.70µg/ml in DPPH radical scavenging assay.  It has shown high levels of phenols (172.6±0.68 mg/g), flavonoids (137.3±0.91 mg/g) and had IC50 values of 422.50 µg/ml and 438.71 µg/ml for amylase and glucosidase, respectively. Conclusion: The results indicate that Polyherbal Formulation (PHF4) had significant antioxidant activity as well as a strong inhibitory effect on α -amylase and α -glucosidase. However, for further validation of the above findings, in vivo antidiabetic study of polyherbal formulation will be carried out using animal models.
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来源期刊
International Journal of Ayurvedic Medicine
International Journal of Ayurvedic Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
50.00%
发文量
87
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