利用蓝光和噬菌体治疗口腔底部和颈部化脓性伤口的现代方法

RS Global, Abdyrakman Moldalievich, Azimbaev Nurlanbek, Moldaliev Mukhtaralievich, Zhoomart Tumakovich, Yeshiev Abdyrakman Moldalievich, Azimbaev Nurlanbek Mukhtaralievich, Moldaliev Zhoomart, Tumakovich
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摘要

最常见的口腔疾病是:龋齿和牙周炎。由于预防水平低和疾病发现不及时,导致并发症(骨膜炎、脓肿、痰等)的发生。颌面部化脓性感染作为普外科的一个科室,在现阶段同样具有重要意义,而且也没有减少的趋势。本研究的目的是研究蓝光照射结合噬菌体治疗化脓性伤口的效果。研究对象是在奥什地区间联合临床医院颌面外科接受治疗的 100 名口腔底部和颈部痰症患者。为了进行等效抗生素治疗,对微生物菌群的数量和质量组成进行了研究。所有口腔底部和颈部痰液患者都按照我们的方法 "用'U'形切口打开口腔底部和颈部痰液的方法(KR 专利第 1876 号)"进行引流。已经证实,使用蓝光和噬菌体进行复合处理,从最初几小时开始就能对化脓伤口产生积极影响。在使用波长为 450 纳米的蓝光和噬菌体治疗化脓性伤口时,伤口愈合过程的主要特点是伤口愈合速度加快,肉芽组织中的成纤维细胞迅速成熟,胶原纤维形成活跃,炎症反应不明显。形态学研究结果表明:中性粒细胞的吞噬活性增强,巨噬细胞和成纤维细胞增殖激活,血管和胶原蛋白生成,肉芽组织加速成熟和纤维化。微生物学研究表明,与传统疗法相比,伤口组织的细菌污染有所减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MODERN APPROACHES TO THE TREATMENT OF PURULENT WOUNDS OF THE BOTTOM OF THE ORAL CAVITY AND NECK WITH THE USE OF BLUE LIGHT AND BACTERIOPHAGES
The most common oral diseases are: dental caries and periodontitis. The low level of prevention and untimely detection of diseases lead to the development of complications (periostitis, abscess, phlegmon, etc.). The problem of purulent infection in the maxillofacial area, as a section of general surgery, is equally relevant at the present stage and also does not show a tendency to decrease. The purpose of the study was to study the effectiveness of treating purulent wounds with blue light irradiation in combination with a bacteriophage. The material for the study was 100 people with phlegmon of the floor of the mouth and neck, who were treated in the Department of Maxillofacial Surgery of the Osh Interregional United Clinical Hospital. To carry out etiotropic antibiotic therapy, the quantitative and qualitative composition of the microbial flora has been studied. All patients with phlegmon of the bottom of the mouth and neck were drained according to our method “Method of opening phlegmon of the bottom of the mouth and neck with a “U” shaped incision (Patent of the KR No. 1876).” It has been established that complex treatment using blue light and bacteriophage has a positive effect on a purulent wound from the first hours. The main feature of the wound process in the treatment of purulent wounds using blue light with a wavelength of 450 nm and bacteriophage is accelerated wound healing, rapid maturation of fibroblasts in granulation tissue, active formation of collagen fibers and a less pronounced inflammatory reaction. Results of morphological studies: an increase in the phagocytic activity of neutrophils, activation of the proliferation of cellular elements of the macrophage and fibroblastic series, angio and collagenogenesis, accelerated maturation and fibrosis of granulation tissue were established. Microbiological studies have shown a decrease in bacterial contamination of wound tissues compared to traditional treatment.
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