加沙地带希法医疗中心内科与非内科泌尿病原体的抗生素耐药性趋势:一项回顾性横断面研究

Alkhodari Khaled, Al-Shurafa Yasmin, AL-louh Hammam, Lubbad Rafat
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摘要

抗生素耐药性是一个日益严重的全球性危机,给医疗保健系统造成了巨大压力,使我们在应对耐药细菌方面的选择十分有限。这项回顾性横断面研究利用微生物实验室一年来的档案数据,研究了希法医院内科与非内科尿路感染(UTI)的抗生素耐药性流行模式。在检查的尿培养物中,约 25% 来自内科部门,而非内科部门的尿培养物数量是内科部门的两倍。阳性率约为 35%,约三分之二的样本来自女性患者。在所有科室中,肠杆菌科细菌是最常见的尿路病原体,占病例总数的 80%。不过,耐药率因具体病原体和使用的抗生素而异。例如,大肠杆菌对美罗培南的耐药率仅为 5%,而对阿莫西林-克拉维酸的耐药率则超过 95%。重要的是,研究显示内科和非内科之间的耐药率存在显著差异,特别是在第三代头孢菌素方面。内科部门的耐药率高得惊人,头孢他啶、头孢曲松和头孢他啶的耐药率分别为 75%、75% 和 66.5%。相比之下,非医疗部门的耐药率较低,分别约为 60%、60% 和 40%。总之,这项研究揭示了尿毒症中抗生素耐药性不断升级的问题,并强调了医疗和非医疗部门之间耐药率的差异。我们亟需努力解决这一问题,找到有效的解决方案,防止无法治疗的细菌感染增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trends of Antibiotic Resistance among Uropathogens in Medical vs. Non-Medical Departments of Al-Shifa Medical Complex in Gaza Strip: A Retrospective, Cross-Sectional Study
Antibiotic resistance is a growing global crisis, straining healthcare systems and leaving us with limited options to combat drug-resistant bacteria. This retrospective, cross-sectional study examines the prevalence of antibiotic resistance patterns among urinary tract infections (UTIs) in Al-Shifa Hospital’s medical departments in comparison with non-medical departments using data from microbiology laboratory archives over a one-year period. From the examined urine cultures about 25% were obtained from internal medicine departments and double the number was obtained from non-medical departments. The positive rate was around 35% and about two-thirds of the samples were collected from female patients. Among all departments, Enterobacteriaceae spp. were found to be the most frequently isolated uropathogens, accounting for 80% of cases. However, resistance rates varied depending on the specific organism and antibiotic used. For instance, E. coli showed a resistance rate of only 5% against meropenem, while amoxicillin-clavulanic acid exhibited a resistance rate exceeding 95%. Importantly, the study revealed a significant disparity in resistance rates between medical and non-medical departments, specifically concerning third-generation cephalosporins. In internal medicine departments, resistance rates were alarmingly high, with cefotaxime, ceftriaxone, and ceftazidime showing resistance rates of 75%, 75% and 66.5% respectively. In contrast, non-medical departments displayed lower resistance rates, approximately 60%, 60% and 40%, respectively. In summary, this research sheds light on the escalating problem of antibiotic resistance in UTIs and emphasizes the discrepancy in resistance rates between medical and non-medical departments. Urgent efforts are required to address this issue and find effective solutions to prevent the rise of untreatable bacterial infections.
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