开角型青光眼风险分层需要哪些实验室检查

IF 0.1 Q4 OPHTHALMOLOGY
Dabin Lee, Hong Kyu Kim
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引用次数: 0

摘要

目的:我们利用韩国国民健康与营养调查(KNHANES)的数据分析了与开角型青光眼(OAG)相关的实验室检查,以加深我们对OAG风险因素的了解:我们将 2008 年至 2012 年期间参与 KNHANES 调查的人分为 OAG 组和非青光眼组。然后,我们进行了多变量分析,并对年龄、性别、教育程度和调查年份进行了调整:结果:两组患者在年龄、性别和受教育程度方面存在显著差异。经过倾向得分匹配后,OAG 组的眼压(IOP)、近视率、收缩压(SBP)和舒张压(DBP)明显升高。此外,该组的高血压和忧郁性情绪障碍患病率以及天门冬氨酸转氨酶/丙氨酸转氨酶(AST/ALT)比值也明显升高。多重逻辑回归显示,眼压升高、SBP、DBP、AST/ALT 比值以及高血压、忧郁情绪和近视的患病率是 OAG 的风险因素:我们的研究揭示了 OAG 的几个风险因素,包括眼压升高、SBP、DBP、AST/ALT 比值、高血压患病率、忧郁情绪和近视。然而,OAG 的发病机制仍不确定。值得注意的是,AST/ALT 比率与 OAG 风险之间呈正相关。需要进一步的研究来评估这种相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What Laboratory Examinations for Open-angle Glaucoma Risk Stratification
Purpose: We analyzed the laboratory examinations associated with open-angle glaucoma (OAG) using data from the Korea National Health and Nutrition Examination Survey (KNHANES) to enhance our understanding of OAG risk factors.Methods: We categorized participants in KNHANES between 2008 and 2012 into OAG and non-glaucomatous groups. Next, we conducted a multivariate analysis, adjusting for age, sex, education level, and survey year.Results: Significant differences were observed in age, sex, and educational levels between the two groups. After propensity score matching, the OAG group demonstrated a significantly elevated intraocular pressure (IOP), myopia prevalence, systolic blood pressure (SBP), and diastolic blood pressure (DBP). In addition, that group exhibited a significantly increased prevalence of hypertension and melancholic mood disorders and aspartate transaminase/alanine transaminase (AST/ALT) ratio. Multiple logistic regression revealed elevated IOP, SBP, DBP, AST/ALT ratio, and prevalence of hypertension, melancholic mood, and myopia as OAG risk factors.Conclusions: Our study revealed several risk factors for OAG, including elevated IOP, SBP, DBP, AST/ALT ratio, and prevalence of hypertension, melancholic mood, and myopia. However, the mechanism underlying OAG remains uncertain. Notably, a positive correlation was observed between the AST/ALT ratio and OAG risk. Further studies are needed to evaluate this association.
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CiteScore
0.20
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126
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