N. S. S. Chalichem, Prathiksha Nabhan, Bharathi Bethapudi, Nikita Agarwal, Sasikumar Murugan, Mundkinajeddu Deepak
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引用次数: 0
摘要
背景：穿心莲（Burm. f.) Nees）是一种广为人知的药用植物，因其对多种疾病有疗效而闻名。本研究旨在评估穿心莲标准化提取物对先天性免疫的影响。材料和方法使用碳清除法测量小鼠的吞噬活性。在另一项实验中，用药后从小鼠脾脏中分离出 NK 细胞（效应细胞），并使用 MTT 试验测定 NK 细胞介导的靶细胞（YAC-1 细胞）裂解率。结果显示在剂量为 41 毫克/千克的受试动物模型中，发现治疗组与对照组相比，吞噬指数和 NK 细胞活性有显著差异（P < 0.05）。结论结果表明，白花蛇舌草具有增强先天免疫力的潜力。
Assessment of Immunomodulatory Activity of AP-Bio® (KalmCold®), a Standardized Extract of Andrographis paniculata Using in vivo and ex vivo Models
Background: Andrographis paniculata (Burm. f.) Nees is a well-recognized medicinal plant known for its benefits against a multitude of ailments. The intent of the present study was to evaluate the effect of a standardized extract of A. paniculata on innate immunity. Materials and Methods: Phagocytic activity was measured in terms of phagocytic index using carbon clearance methodology in mice. In another experiment, NK cells (effector cells) were isolated from the mouse spleen after the dosing period, and NK cells-mediated lysis of target cells (YAC-1 cells) were determined using an MTT assay. Results: The phagocytic index and NK cell activity were found to be significantly ( p < 0.05) different in the treated group compared to the control group in the tested animal models at a dose of 41 mg/kg. Conclusion: The results suggest the potential of A. paniculata to enhance innate immunity.
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