{"title":"艾滋病毒感染与肠道微生物群","authors":"A. A. Khryanin, E. V. Pushkarev, V. K. Bocharova","doi":"10.22328/2077-9828-2023-15-4-25-35","DOIUrl":null,"url":null,"abstract":"In this analytical review, the authors present current views on the relationship between the persistence of HIV infection and the gut microbiome in people living with HIV (PLHIV). The study of this issue remains highly relevant for various reasons, because HIV-associated dysbiosis may underlie chronic diseases that persist and progress throughout the entire period of HIV infection, despite the control of viral load achieved with antiretroviral therapy (ART). The identification of close pathogenetic links between intestinal bacteria and HIV-associated diseases contributes to the development of new treatments aimed at changing the intestinal microbiome. It has been demonstrated that the gut microbiome has the potential to influence HIV disease at every stage of the viral life cycle, from infection through AIDS, opening the door for therapeutic interventions targeting the gut microbiome at each of these stages. Modern therapeutic strategies, including ART and agents aimed to normalizing the gut microbiome and reducing systemic chronic inflammation, may influence the existence of the HIV reservoir and thereby provide a cure for HIV infection.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" 36","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HIV infection and the gut microbiome\",\"authors\":\"A. A. Khryanin, E. V. Pushkarev, V. K. Bocharova\",\"doi\":\"10.22328/2077-9828-2023-15-4-25-35\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this analytical review, the authors present current views on the relationship between the persistence of HIV infection and the gut microbiome in people living with HIV (PLHIV). The study of this issue remains highly relevant for various reasons, because HIV-associated dysbiosis may underlie chronic diseases that persist and progress throughout the entire period of HIV infection, despite the control of viral load achieved with antiretroviral therapy (ART). The identification of close pathogenetic links between intestinal bacteria and HIV-associated diseases contributes to the development of new treatments aimed at changing the intestinal microbiome. It has been demonstrated that the gut microbiome has the potential to influence HIV disease at every stage of the viral life cycle, from infection through AIDS, opening the door for therapeutic interventions targeting the gut microbiome at each of these stages. Modern therapeutic strategies, including ART and agents aimed to normalizing the gut microbiome and reducing systemic chronic inflammation, may influence the existence of the HIV reservoir and thereby provide a cure for HIV infection.\",\"PeriodicalId\":37381,\"journal\":{\"name\":\"HIV Infection and Immunosuppressive Disorders\",\"volume\":\" 36\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"HIV Infection and Immunosuppressive Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22328/2077-9828-2023-15-4-25-35\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV Infection and Immunosuppressive Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22328/2077-9828-2023-15-4-25-35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
In this analytical review, the authors present current views on the relationship between the persistence of HIV infection and the gut microbiome in people living with HIV (PLHIV). The study of this issue remains highly relevant for various reasons, because HIV-associated dysbiosis may underlie chronic diseases that persist and progress throughout the entire period of HIV infection, despite the control of viral load achieved with antiretroviral therapy (ART). The identification of close pathogenetic links between intestinal bacteria and HIV-associated diseases contributes to the development of new treatments aimed at changing the intestinal microbiome. It has been demonstrated that the gut microbiome has the potential to influence HIV disease at every stage of the viral life cycle, from infection through AIDS, opening the door for therapeutic interventions targeting the gut microbiome at each of these stages. Modern therapeutic strategies, including ART and agents aimed to normalizing the gut microbiome and reducing systemic chronic inflammation, may influence the existence of the HIV reservoir and thereby provide a cure for HIV infection.
期刊介绍:
In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.