艾滋病毒感染与肠道微生物群

Q4 Medicine
A. A. Khryanin, E. V. Pushkarev, V. K. Bocharova
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引用次数: 0

摘要

在这篇分析性综述中,作者介绍了目前关于艾滋病病毒感染持续存在与艾滋病病毒感染者(PLHIV)肠道微生物组之间关系的观点。由于种种原因,对这一问题的研究仍然具有高度的现实意义,因为尽管抗逆转录病毒疗法(ART)控制了病毒载量,但在整个艾滋病病毒感染期间,与艾滋病病毒相关的菌群失调可能是慢性疾病持续存在和发展的基础。确定肠道细菌与艾滋病相关疾病之间的密切致病联系有助于开发旨在改变肠道微生物组的新疗法。研究表明,肠道微生物组有可能在病毒生命周期的每个阶段(从感染到艾滋病)影响艾滋病毒疾病,这为在每个阶段针对肠道微生物组进行治疗干预打开了大门。现代治疗策略,包括抗逆转录病毒疗法和旨在使肠道微生物组正常化和减少全身慢性炎症的药物,可能会影响艾滋病毒储库的存在,从而治愈艾滋病毒感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HIV infection and the gut microbiome
In this analytical review, the authors present current views on the relationship between the persistence of HIV infection and the gut microbiome in people living with HIV (PLHIV). The study of this issue remains highly relevant for various reasons, because HIV-associated dysbiosis may underlie chronic diseases that persist and progress throughout the entire period of HIV infection, despite the control of viral load achieved with antiretroviral therapy (ART). The identification of close pathogenetic links between intestinal bacteria and HIV-associated diseases contributes to the development of new treatments aimed at changing the intestinal microbiome. It has been demonstrated that the gut microbiome has the potential to influence HIV disease at every stage of the viral life cycle, from infection through AIDS, opening the door for therapeutic interventions targeting the gut microbiome at each of these stages. Modern therapeutic strategies, including ART and agents aimed to normalizing the gut microbiome and reducing systemic chronic inflammation, may influence the existence of the HIV reservoir and thereby provide a cure for HIV infection.
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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