{"title":"无催化剂脱羧烷基化：进入季中心","authors":"Lulan Cai, Fang Li, Shuting Wang, Wentao Xu","doi":"10.20517/cs.2023.57","DOIUrl":null,"url":null,"abstract":"The formation of C(sp3)−C(sp3) bonds has received continuous attention in organic synthesis, and the focus on versatile alkyl precursors remains constant. In our work, prevalent amines and carboxylic acids successfully serve as alkyl sources to construct C(sp3)−C(sp3) bonds via decarboxylative deamination. The catalyst-free decarboxylative alkylation reaction provides alternative access to the quaternary center. Primary mechanistic experiments suggest that it undergoes a polar mechanism.","PeriodicalId":381136,"journal":{"name":"Chemical Synthesis","volume":" 457","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Catalyst-free decarboxylative alkylation: access to quaternary center\",\"authors\":\"Lulan Cai, Fang Li, Shuting Wang, Wentao Xu\",\"doi\":\"10.20517/cs.2023.57\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The formation of C(sp3)−C(sp3) bonds has received continuous attention in organic synthesis, and the focus on versatile alkyl precursors remains constant. In our work, prevalent amines and carboxylic acids successfully serve as alkyl sources to construct C(sp3)−C(sp3) bonds via decarboxylative deamination. The catalyst-free decarboxylative alkylation reaction provides alternative access to the quaternary center. Primary mechanistic experiments suggest that it undergoes a polar mechanism.\",\"PeriodicalId\":381136,\"journal\":{\"name\":\"Chemical Synthesis\",\"volume\":\" 457\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Synthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20517/cs.2023.57\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20517/cs.2023.57","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Catalyst-free decarboxylative alkylation: access to quaternary center
The formation of C(sp3)−C(sp3) bonds has received continuous attention in organic synthesis, and the focus on versatile alkyl precursors remains constant. In our work, prevalent amines and carboxylic acids successfully serve as alkyl sources to construct C(sp3)−C(sp3) bonds via decarboxylative deamination. The catalyst-free decarboxylative alkylation reaction provides alternative access to the quaternary center. Primary mechanistic experiments suggest that it undergoes a polar mechanism.
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