与埃塞俄比亚一家三级医疗中心接受治疗的艾滋病毒感染者神经认知功能障碍相关的因素

Q3 Medicine
Biniyam Alemayehu Ayele, Kiran T. Thakur, W. Amogne
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引用次数: 0

摘要

背景:随着撒哈拉以南非洲地区艾滋病病毒感染者(PLWH)预期寿命的延长,无症状艾滋病病毒相关神经认知障碍(HAND)的风险也随之增加。研究目的是调查埃塞俄比亚接受过治疗的成年人中 HAND 的患病率及相关因素:在 2019 年 12 月至 2020 年 6 月期间开展了一项单中心观察性横断面研究,以调查 HAND。国际艾滋病痴呆量表(IHDS)用于筛查该疾病。研究采用描述性和分析性统计方法对数据进行分析:共有 324 名接受联合抗逆转录病毒治疗的 PLWH(63% 为女性)接受了调查,他们的中位数为 144 个月(IQR:108-168)。平均年龄为 42.5 岁(1SD=12.2)。手足口病的发病率为 75.3%,40 岁以上人群的发病率明显更高(65.8% 对 80.7%,P=0.003)。年龄是通过多变量逻辑回归分析确定的唯一风险因素。 随着患者年龄的增长,认知能力总分呈线性下降;年龄占 IHDS 分值变化的 9.4% (r= -0.31, R2=0.094, p<0.0001)。虽然在统计学上并不显著,但在被诊断为手足口病的人群中,心脏代谢和行为风险因素(高血压、糖尿病、血脂异常、吸烟、酗酒和使用阿拉伯茶)的趋势更高:结论:与 40 岁以下人群相比,40 岁及以上的艾滋病病毒抗体阳性者的神经认知功能障碍更为明显。年龄是预测 HAND 的一个独立因素。与非 HAND 患者相比,HAND 患者的心血管和行为风险因素更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Associated with Neurocognitive Impairment in Treatment Experienced HIV+ Adults from a Tertiary Care Center in Ethiopia
Background: Given the improvement in life expectancy of people living with HIV (PLWH) in sub-Saharan Africa, the risk of asymptomatic HIV-associated neurocognitive disorder (HAND) has increased. The study objectives were to investigate the prevalence of HAND and  associated factors among treatment experienced adults in Ethiopia.Methods: A single-center observational cross-sectional study was conducted between December 2019 and June 2020 to investigate  HAND. International HIV dementia scale (IHDS) was used to screen for the disorder. Both descriptive and analytical statistics were used to  analyze the data.Results: Total of 324 PLWH (63% females) who were on combination antiretroviral therapy for median of 144 months (IQR: 108-168) were  investigated. The mean age was 42.5 years (1SD=12.2). The prevalence of HAND was 75.3% and the difference was significantly more in  those above 40 years of age (65.8% vs. 80.7%, p=0.003). Age is the only risk factor identified with multivariable logistic regression analysis.  A linear decrement in the total score of cognitive performance was observed as the patient’s age increase; age was responsible  for 9.4% variation observed in IHDS score (r= -0.31, R2=0.094, p<0.0001). Although statistically not-significant, the trend for  cardiometabolic and behavioral risk factors (hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol and khat use) was higher in  the group diagnosed with HAND.Conclusion: The occurrence of neurocognitive impairment was more pronounced in individuals aged 40 years and above who were HIV  positive, compared to those below 40 years. Age was found to be an independent predictor of HAND. Cardiovascular and behavioral risk  factors were observed more among patients with HAND compared to no-HAND.
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来源期刊
Ethiopian Medical Journal
Ethiopian Medical Journal Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
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0
期刊介绍: The Ethiopian Medical Journal (EMJ) is the official Journal of the Ethiopian Medical Association (EMA) and devoted to the advancement and dissemination of knowledge pertaining to the broad field of medicine in Ethiopia and other developing countries. Prospective contributors to the Journal should take note of the instructions of Manuscript preparation and submission to EMJ as outlined below.
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