2022 年 6 月至 2023 年 6 月期间兰塞特综合医院住院患者的细菌学特征、抗生素耐药性模式和预后：回顾性队列研究

Q3 Medicine

Ethiopian Medical Journal Pub Date : 2024-01-19 DOI:10.4314/emj.v62i1.3

Zekewos Demissie, Serkalem Nurlegn, Nahom Zemedkun, Yidnekachew Demssis, Bethel Mekuriya, Eyob Beyene, Seifemichael Getachew, Desalew Mekonnen, Yohannes Birhanu, Brook Alemayehu, Nebiyat Sileshi, Gelila Sintayehu, D. Admasu, Kibruyisfaw Zewdie

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引用次数: 0

摘要

背景：先前的研究表明，埃塞俄比亚的抗菌药耐药性有所增加，并带来了相关的健康、经济和环境成本。了解机构和人群的微生物学概况有助于进行适当的抗生素治疗，这对患者的治疗效果（如医疗相关成本、发病率和死亡率）有重大影响。本研究评估了兰塞特综合医院的细菌学概况、耐药性模式和治疗效果。研究方法对 2022 年 6 月至 2023 年 6 月期间兰塞特综合医院收治的 128 名符合条件的患者的细菌学特征、抗生素耐药模式和治疗效果进行了回顾性队列研究。分析了所有经培养确诊感染的住院患者的数据。数据分析采用 SPSS 26.0 版。使用二元逻辑回归模型分析自变量和因变量之间的关系。结果77%的病例回收了革兰氏阴性菌。37.5%（54 例）的分离菌株中发现了产生广谱β-内酰胺酶的肠杆菌科细菌，27.8%的患者对碳青霉烯类耐药。耐多药细菌感染的院内死亡率为 14.8%。年龄≥65岁、出现脓毒性休克和耐碳青霉烯类细菌与院内死亡率升高密切相关。结论大量耐药微生物被分离出来，耐碳青霉烯类细菌引起的感染导致死亡率升高。应开展多中心研究，以确定全国各地医疗机构中耐药微生物的程度和流行病学，并将研究结果纳入临床决策和疾病预防、筛查和治疗的方案设计中。该报告还呼吁进一步开展前瞻性研究，以便结合更多相关的个人和临床特征了解更多情况。

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Bacteriologic Profile, Antibiotics Resistance Pattern, and Outcomes of Patients Admitted to Lancet General Hospital from June 2022 to June 2023: A Retrospective Cohort Study

Background: Prior studies indicated increased antimicrobial resistance in Ethiopia, with related health, economic, and environmental costs. Knowing an institutions and population microbiologic profile allows for proper antibiotic treatment, which substantially impact patients’ outcomes such as healthcare related costs, morbidity, and mortality. The current study assessed the bacteriologic profile, resistance pattern, and treatment outcome in Lancet General Hospital. Method: A retrospective cohort study on the bacteriologic profile, antibiotics resistance pattern, and outcome of patients was done on 128 eligible patients who were admitted to Lancet General Hospital from June 2022 to June 2023. Data from all hospitalized patients with culture-confirmed infection were analyzed. SPSS version 26.0 was used to analyze the data. Association between independent and dependent variables was analyzed using binary logistic regression model. Results: Gram-negative bacteria were recovered in 77% of the cases. Extended-spectrum beta-lactamase producing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. In-hospital mortality from multidrug resistant bacterial infection was 14.8%. Age ≥ 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with increased in-hospital mortality. Conclusion: High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country.epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. It also calls for further prospective research to learn more about the conditions in the context of additional relevant personal and clinical characteristics

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来源期刊

Ethiopian Medical Journal Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： The Ethiopian Medical Journal (EMJ) is the official Journal of the Ethiopian Medical Association (EMA) and devoted to the advancement and dissemination of knowledge pertaining to the broad field of medicine in Ethiopia and other developing countries. Prospective contributors to the Journal should take note of the instructions of Manuscript preparation and submission to EMJ as outlined below.