环状胺的合成与 alpha-官能化

Synlett Pub Date : 2024-01-22 DOI:10.1055/a-2251-4145

Margaret Brimble, Ze Kuang, Xiaobo Ding, D. Furkert

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引用次数: 0

摘要

 对环亚胺的功能化进行了探索。利用亲核加成/环化顺序，从各自的卤腈前体合成了环亚胺底物。环状亚胺的选择性单卤化反应产生了α-卤化亚胺，并以此为平台获得了各种α-羟基亚胺衍生物。此外，在尝试制备α-羟基亚胺的过程中，还观察到不寻常的同分异构和氧化顺序。

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Synthesis and alpha-Functionalisation of Cyclic Imines

-Functionalisation of cyclic imines has been explored. The cyclic imine substrates were synthesised from their respective halonitrile precursors using a nucleophilic addition/cyclisation sequence. Selective monohalogenation of the cyclic imines yielded alpha-haloimines, which served as a platform to obtain various alpha-hydroxyimine derivatives. In addition, an unusual tautomerisation and oxidation sequence was observed in the attempted preparation of alpha-hydroxyimines.

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