葡萄糖-水协同作用：一种有机催化系统驱动的苯并咪唑并[2,3-b]喹唑啉酮和苯并噻唑并[2,3-b]喹唑啉酮衍生物的合成方法

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2024-01-24 DOI:10.2174/0122133372274183231218063119

J. Baranwal, Swastika Singh, Smriti Kushwaha, Archana Jyoti

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引用次数: 0

摘要

在这项工作中，葡萄糖水被用作一种绿色的、可重复使用的、对环境无害的有机催化溶剂系统来合成所需的产物。总之，我们成功地开发出了一种以葡萄糖水为有机催化介质、对环境无害的苯并咪唑/苯并噻唑喹唑啉酮的绿色合成方法。

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Glucose-Water Synergy: An Organocatalytic System Driven synthesis of Benzimidazolo[2,3-b]quinazolinone and Benzothiazolo[2,3-b]quinazolinone Derivatives

A simple and efficient one-pot synthesis of quinazolinone derivatives has been developed via a multicomponent reaction (MCR) involving the condensation of dimedone, benzaldehyde, and 2-aminobenzimidazole/2-aminobenzothiazole. In this work, glucose water is used as a green, reusable, environmentally benign organocatalytic solvent system to synthesize desired products. The main benefits of this one-pot method include its excellent yields, less time, cost-effectiveness, atom economy, environment benign, and easy workup. In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of benzimidazo/benzothiazolo quinazolinones using glucose water as an organocatalytic medium

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.