详细回顾免疫疗法,特别强调杂交瘤技术

Arunkumar Ramjibhai Vaghela, Tejas H. Ganatra
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摘要

本文以杂交瘤为重点,对免疫疗法进行了深入分析。它描述了免疫疗法是如何利用抗体和杂交瘤技术对癌症、自身免疫性疾病和传染病等多种疾病进行集中和精确治疗的。这种方法生产的主要疗法是单克隆抗体(mAbs)。文章介绍了杂交瘤技术的过程,即通过将永生化骨髓瘤细胞与 B 淋巴细胞结合,产生能产生独特 mAbs 的异质细胞群。为了分离和制造药物制剂,需要选择能产生所需抗体的杂交瘤细胞并进行大量培养。文章重点介绍了基于抗体和杂交瘤技术的免疫疗法的成功应用。杂交瘤技术用于治疗自身免疫性疾病、病毒感染和癌症。文章还介绍了 mAbs 在扩大可用治疗范围方面的潜力。该页还介绍了单克隆抗体和多克隆抗体的区别、制造方法,以及杂交瘤技术在研究、诊断、治疗、疫苗开发和基础免疫学调查中的不同用途。本章最后强调了基于抗体和杂交瘤技术的免疫疗法在彻底改变治疗环境以及为定制和靶向疗法创造新机遇方面的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A detailed review of immunotherapeutics with a special emphasis on hybridoma technology
The paper offers a thorough analysis of immunotherapeutics with a focus on hybridomas. It describes how focused and precise treatments for a variety of illnesses, such as cancer, autoimmune disorders, and infectious diseases, have been made possible by immunotherapeutics, which are based on antibody and hybridoma technology. The main therapeutics produced by this method are monoclonal antibodies (mAbs). The article describes the hybridoma technology process, in which a heterogeneous population of cells that produce unique mAbs are created by combining immortalized myeloma cells with B lymphocytes. To isolate and create drug formulations, the hybridoma cells that produce the desired antibodies are chosen and grown in large numbers. In the article, successful uses of immunotherapeutics based on antibody and hybridoma technology are highlighted. Hybridoma technology used in treatment of autoimmune conditions, viral infections and cancer. The potential of mAbs to increase the range of available treatments is also covered. The page also describes the distinction between monoclonal and polyclonal antibodies, how they are made, and the different uses of hybridoma technology in research, diagnostics, therapy, vaccine development, and fundamental immunology investigations. The importance of immunotherapeutics based on antibody and hybridoma technologies in revolutionizing the treatment environment and creating new opportunities for customized and targeted therapies is emphasized as it draws to a close.
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