应对多重耐药菌技术的瞬时比较:遏制细菌感染的主要模块

M. Naveed, Muhammad Waseem, Izma Mahkdoom, Nouman Ali, Farrukh Asif, J. Hassan, Hamza Jamil
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引用次数: 0

摘要

耐多药生物是指不再被特定药物控制或杀死的细菌。导致细菌产生耐多药(MDR)的方法有两种:第一,这些细菌可能会将编码耐药的多个细胞基因伪装在耐药(R)质粒上,以抵抗单一疗法。其次,多药外排泵编码基因的表达量增加也会导致 MDR,这种多药外排泵可挤出多种药物。抗生素耐药性是一个大问题,因为有些细菌几乎可以耐受所有抗生素。这些细菌可导致严重疾病,对公共健康构成威胁。耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)、耐多药结核分枝杆菌(TB)和 CRE 都是耐抗生素的肠道细菌。抗菌药耐药性在全球范围内不断上升,增加了临床和社区的发病率和死亡率。超级细菌使得某些环境中的抗生素耐药性更加难以控制。本研究介绍了新的药用植物、基因编辑方法、纳米材料和细菌疫苗,它们将在未来对抗 MDR 细菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transient comparison of techniques to counter multi-drug resistant bacteria: prime modules in curation of bacterial infections
Multidrug-resistant organisms are bacteria that are no longer controlled or killed by specific drugs. One of two methods causes bacteria multidrug resistance (MDR); first, these bacteria may disguise multiple cell genes coding for drug resistance to a single treatment on resistance (R) plasmids. Second, increased expression of genes coding for multidrug efflux pumps, which extrude many drugs, can cause MDR. Antibiotic resistance is a big issue since some bacteria may withstand almost all antibiotics. These bacteria can cause serious sickness, making them a public health threat. Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Multidrug resistant Mycobacterium tuberculosis (TB), and CRE are gut bacteria that resist antibiotics. Antimicrobial resistance is rising worldwide, increasing clinical and community morbidity and mortality. Superbugs have made antibiotic resistance in some environmental niches even harder to control. This study introduces new medicinal plants, gene-editing methods, nanomaterials, and bacterial vaccines that will fight MDR bacteria in the future.
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