肾细胞癌胰腺转移的重复胰腺切除术：一项西班牙多中心研究（PANMEKID）

IF 2.3 4区医学 Q3 ONCOLOGY

Surgical Oncology-Oxford Pub Date : 2024-02-01 DOI:10.1016/j.suronc.2024.102039

Adela Rojas-Holguín , Constantino Fondevila-Campo , Alfonso Sanjuanbenito , Joan Fabregat-Prous , Luís Secanella-Medayo , Fernando Rotellar-Sastre , Fernando Pardo-Sánchez , Mikel Prieto-Calvo , Héctor Marín-Ortega , Santiago Sánchez-Cabús , Luis Diez-Valladares , Óscar Alonso-Casado , Carmen González-Serrano , Juan Carlos Rodríguez-Sanjuan , Gabriel García-Plaza , Isabel Jaén-Torrejimeno , Miguel Ángel Suárez-Muñoz , Antonio Becerra-Massare , Paula Senra-del Rio , Elizabeth Pando , Gerardo Blanco-Fernández

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引用次数: 0

摘要

背景和目的胰腺切除术后肾细胞癌（RCC）复发孤立性胰腺转移非常罕见。我们的研究旨在描述一系列肾癌胰腺转移灶在胰腺残余部位复发的病例，以及通过重复胰腺切除术对其进行手术治疗的情况，并分析总生存期和无病生存期的结果。方法对2010年1月至2020年5月期间因RCC胰腺转移灶接受胰腺切除术的患者进行多中心回顾性研究。根据患者接受的是单次胰腺切除术（SPS）还是迭代胰腺切除术，将患者分为两组。研究收集了胰腺切除术后短期和长期疗效的数据。其中，15 名患者接受了胰腺迭代手术（IPS）。第一次胰腺手术与第二次手术之间的平均间隔时间为 48.9 个月（95 % CI：22.2-56.9）。术后并发症发生率没有差异。IPS组和SPS组1年、3年和5年的DFS率分别为86%、78%和78%，而IPS组为75%、50%和37%（P = 0.179）。IPS组1年、3年、5年和7年的OS分别为100%、100%、100%和75%，SPS组分别为95%、85%、80%和68%（P = 0.895）。

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查看原文本刊更多论文

Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Background and objectives

Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival.

Methods

Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected.

Results

The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2–56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895).

Conclusion

Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.