从 Adhatod avasica 提取的生物大分子作为治疗 COVID-19 病毒变种的天然有效分子的抗病毒潜力

IF 0.7 4区 化学 Q4 CHEMISTRY, ORGANIC
Mohammad Asif, Mohd Yusuf, Mazen M. Almehmadi, Ahad Alsaiari, Mamdouh Allahyani, Abdulelah Aljuaid, Abdulaziz Alsharif
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引用次数: 0

摘要

:Adhatoda vasica (L.)(刺桐科)具有重要的治疗作用,被广泛应用于本土医药系统或阿育吠陀医药系统。本研究的重要目的是报告 A. vasica 中存在的不同植物化学物质的硅内抗电晕(COVID-19)活性。这项研究将有助于找到特定的生物活性化合物,并将其用作抗 COVID-19 的药物,以造福人类。瓦斯草(A. vasica)中的植物化学成分具有多种药理活性。这些植物成分对多种疾病具有活性,如抗菌、抗结核、抗病毒、止咳、保肝、抗炎、抗溃疡、抗尿崩症、堕胎、放射调节剂、心脏保护、抗糖尿病、抗氧化、抗癌、溶栓、抗突变等。在当前保护环境和安全使用的大环境下,研究人员受到诱惑,开始使用具有巨大治疗潜力的天然和可持续产品。这些材料具有生物活性、安全性和与环境的兼容性。我们利用 SARS-CoV-2 穗状受体 (6M0J),评估了 Covid-19 变体 (RBD- COV-2-S) 的 Adhatoda vasica 生物分子。这项研究非常令人鼓舞,表明应更广泛地研究草药的治疗功效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant
: Adhatoda vasica (L.) (Acanthaceae) has essential therapeutic roles and is widely used in the indigenous medicine system or Ayurvedic system of medicine. The important goals of the present study are to report the in-silico anti-corona (COVID-19) activity of different phytochemicals present in A. vasica. This study will help to find specific bioactive compounds, and their use as anti- COVID-19 action for human welfare. A. vasica has chemical phytoconstituents with diverse pharmacological activities. These phytoconstituents have been found active against many diseases such as antibacterial, antitubercular, antivirus, antitussive, hepatoprotective, antiinflammatory, antiulcer, antiurolithiatic, abortifacient, radio modulator, cardio-protection, antidiabetic, antioxidant, anticancer, thrombolytic, antimutagenic, etc. Researchers have been lured to the use of natural and sustainable products with substantial therapeutic potential in the current climate of environmental preservation and safe use. These materials permit biological activity, safety, and compatibility with the environment. Using the SARS-CoV-2 spike receptor (6M0J), we evaluated Adhatoda vasica biomolecules for the Covid-19 variant (RBD- COV-2-S). This study is very encouraging and indicates that herbs should be studied more extensively for their therapeutic benefits.
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来源期刊
Letters in Organic Chemistry
Letters in Organic Chemistry 化学-有机化学
CiteScore
1.30
自引率
12.50%
发文量
135
审稿时长
7 months
期刊介绍: Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.
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