心理想象减少酒精使用障碍和酒精相关肝损伤患者的酒精相关伤害:MIRAGE 随机试点试验结果。

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Ashwin Dhanda, Jackie Andrade, Hannah Allende, Victoria Allgar, Matthew Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Wendy Ingram, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C Anne McCune, Crispin Musicha, Richard Parker, Christopher Rollinson, Jonny Wilks, E Siobhan Creanor
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引用次数: 0

摘要

目的:酒精相关肝病(ARLD)造成的医疗负担日益加重。控制酒精相关性肝病和酒精使用障碍(AUD)的最佳方法是减少或停止饮酒,但目前缺乏有效的治疗方法。我们测试了入院的酒精相关性肝病(ARLD)和酒精使用障碍(AUD)患者能否被招募并继续参加功能想象训练(FIT)试验,这是一种利用心理想象来减少酒精渴求的心理疗法。我们对入院的ARLD和AUD患者进行了一项多中心随机试点试验,对通常治疗(TAU)与FIT+TAU进行了对比:参与者被随机分配到TAU(一次简短干预)或FIT+TAU(TAU加上一次医院FIT疗程,然后在6个月内进行8次电话疗程)。试验结果包括招募率和第180天的保留率。次要结果包括 FIT 实施的忠实度、酒精使用情况和酒精依赖的严重程度:共招募并随机分配了 54 名参与者(平均年龄 49 岁;63% 为男性),其中 28 人接受 TAU 治疗,26 人接受 FIT+TAU 治疗。第 180 天的保留率为 43%。大多数酒精护理人员都能充分开展 FIT。50%的干预参与者完成了 FIT 第 1 和第 2 个疗程。治疗组之间在第180天的酒精使用或酒精依赖严重程度方面没有差异:结论:FIT 与 FIT+TAU 的试验可以招募到患有 ARLD 和 AUD 的参与者。然而,第 180 天的保留率并不理想。在对这一患者群体进行FIT的最终试验之前,必须对干预措施和招募/保留策略的修改进行测试。试验注册号:ISRCTN41353774。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results.

Objective: The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether people with ARLD and AUD admitted to hospital could be recruited to and retained in a trial of Functional Imagery Training (FIT), a psychological therapy that uses mental imagery to reduce alcohol craving. We conducted a multicentre randomised pilot trial of treatment as usual (TAU) versus FIT+TAU in people admitted to hospital with ARLD and AUD.

Design: Participants were randomised to TAU (a single session of brief intervention) or FIT+TAU (TAU with one hospital-based FIT session then eight telephone sessions over 6 months). Pilot outcomes included recruitment rate and retention at day 180. Secondary outcomes included fidelity of FIT delivery, alcohol use, and severity of alcohol dependence.

Results: Fifty-four participants (mean age 49; 63% male) were recruited and randomised, 28 to TAU and 26 to FIT+TAU. The retention rate at day 180 was 43%. FIT was delivered adequately by most alcohol nurses. 50% of intervention participants completed FIT sessions 1 and 2. There were no differences in alcohol use or severity of alcohol dependence between treatment groups at day 180.

Conclusion: Participants with ARLD and AUD could be recruited to a trial of FIT versus FIT+TAU. However, retention at day 180 was suboptimal. Before conducting a definitive trial of FIT in this patient group, modifications in the intervention and recruitment/retention strategy must be tested.

Trial registration number: ISRCTN41353774.

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来源期刊
BMJ Open Gastroenterology
BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.90
自引率
3.20%
发文量
68
审稿时长
2 weeks
期刊介绍: BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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