透过迷雾看世界：COVID 后认知障碍的神经内分泌解释

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-01-29 DOI:10.1038/s41574-024-00955-3

S. Rasika, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot

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引用次数: 0

摘要

促性腺激素释放激素与认知功能有关，而促性腺激素释放激素的丧失是大脑病理性老化的一个因素。这些过程与在长COVID患者身上观察到的神经和认知缺陷之间存在相似之处。在此，我们探讨了与长COVID相关的神经解剖学和转录组学改变可能源于这种神经内分泌干扰的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits

Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanatomical and transcriptomic alterations associated with long COVID could stem from this neuroendocrine perturbation.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.