类风湿性关节炎的流行病学和发病风险因素。

Q4 Medicine
Mediterranean Journal of Rheumatology Pub Date : 2023-12-30 eCollection Date: 2023-12-01 DOI:10.31138/mjr.301223.eaf
Aliki I Venetsanopoulou, Yannis Alamanos, Paraskevi V Voulgari, Alexandros A Drosos
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种全球流行的慢性炎症性关节炎,对患者和人口健康造成严重影响。该病主要影响女性,女性与男性的比例为三比一。其发病机制是多因素的,包括遗传和环境风险因素。流行病学研究强调了环境与遗传易感性之间的联系。所谓的共享表位是最重要的风险因素,似乎与其他环境因素在疾病发生中起着协同作用。此外,最近的研究结果表明,新的重要环境因素,如观察到的地球自然资源污染,对疾病的易感性和进展也有潜在作用。本综述总结了有关 RA 的流行病学、遗传、环境和生活方式风险因素的最具决定性的证据。它表明,将遗传和环境因素联系起来研究,可以制定出可能影响疾病自然史的预防策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology and Risk Factors for Rheumatoid Arthritis Development.

Rheumatoid arthritis (RA) is a prevalent chronic inflammatory arthritis worldwide, significantly impacting patients and population health. The disease affects women primarily, with a female-to-male ratio of three to one. Its pathogenesis is multifactorial, including genetic and environmental risk factors. Epidemiological studies highlight the link between the environment and genetic susceptibility to RA. The so-called shared epitope is the most significant risk factor that seems to act synergetic with other environmental factors in the disease occurrence. In addition, recent findings suggest a potential role of new substantial environmental factors, such as the observed pollution of the planet's natural resources, on the susceptibility and progression of the disease. This review summarises the most decisive evidence on epidemiology and genetic, environmental, and lifestyle risk factors for RA. It shows that studying genetic and environmental factors in correlation could lead to prevention strategies that may impact the natural history of the disease.

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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
42
审稿时长
8 weeks
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