Benedikt Schrenker , Anna Zimmermann , Thorsten Koch , Grit Walther , Ronny Martin , Daniel Kampik , Oliver Kurzai , Johanna Theuersbacher
{"title":"基于聚己内酯的隐形眼镜储液对镰刀菌的抗真菌活性经常不足","authors":"Benedikt Schrenker , Anna Zimmermann , Thorsten Koch , Grit Walther , Ronny Martin , Daniel Kampik , Oliver Kurzai , Johanna Theuersbacher","doi":"10.1016/j.ijmm.2024.151602","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p><em>Fusarium</em> keratitis is a severe infection of the anterior eye, frequently leading to keratoplasty or surgical removal of the affected eye. A major risk factor for infection is the use of contact lenses. Inadequate hygiene precautions and mold-growth permissive storage fluids are important risk factors for fungal keratitis. The aim of this study was to comparatively analyze contact lens storage fluids disinfection efficacy against <em>Fusarium</em> species.</p></div><div><h3>Methods</h3><p>Eleven commercially available storage fluids were tested. The storage fluids were classified according to their active ingredients myristamidopropyldimethylamine (Aldox), polyhexanide and hydrogen peroxide. Efficacy was tested against isolates belonging to the <em>Fusarium solani</em> and <em>Fusarium oxysporum</em> species complexes as the most common agents of mould keratitis. Tests were carried out based on DIN EN ISO 14729.</p></div><div><h3>Results</h3><p>All Aldox and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) based fluids were effective against <em>Fusarium</em> spp., while the majority of polyhexanide based storage fluids showed only limited or no antifungal effects. Efficacy of polyhexanide could be restored by the addition of the pH-regulating agent tromethamine - an additive component in one commercially available product.</p></div><div><h3>Conclusions</h3><p>In summary, the use of Aldox- or hydrogen peroxide-based storage fluids may reduce the risk of <em>Fusarium</em> keratitis, while polyhexanide-based agents largely lack efficacy against <em>Fusarium</em>.</p></div>","PeriodicalId":50312,"journal":{"name":"International Journal of Medical Microbiology","volume":"314 ","pages":"Article 151602"},"PeriodicalIF":4.5000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438422124000067/pdfft?md5=e95ff8ddac5e11989d252e6f9ed43c19&pid=1-s2.0-S1438422124000067-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Polyhexanide based contact lens storage fluids frequently exhibit insufficient antifungal activity against Fusarium species\",\"authors\":\"Benedikt Schrenker , Anna Zimmermann , Thorsten Koch , Grit Walther , Ronny Martin , Daniel Kampik , Oliver Kurzai , Johanna Theuersbacher\",\"doi\":\"10.1016/j.ijmm.2024.151602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p><em>Fusarium</em> keratitis is a severe infection of the anterior eye, frequently leading to keratoplasty or surgical removal of the affected eye. A major risk factor for infection is the use of contact lenses. Inadequate hygiene precautions and mold-growth permissive storage fluids are important risk factors for fungal keratitis. The aim of this study was to comparatively analyze contact lens storage fluids disinfection efficacy against <em>Fusarium</em> species.</p></div><div><h3>Methods</h3><p>Eleven commercially available storage fluids were tested. The storage fluids were classified according to their active ingredients myristamidopropyldimethylamine (Aldox), polyhexanide and hydrogen peroxide. Efficacy was tested against isolates belonging to the <em>Fusarium solani</em> and <em>Fusarium oxysporum</em> species complexes as the most common agents of mould keratitis. Tests were carried out based on DIN EN ISO 14729.</p></div><div><h3>Results</h3><p>All Aldox and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) based fluids were effective against <em>Fusarium</em> spp., while the majority of polyhexanide based storage fluids showed only limited or no antifungal effects. Efficacy of polyhexanide could be restored by the addition of the pH-regulating agent tromethamine - an additive component in one commercially available product.</p></div><div><h3>Conclusions</h3><p>In summary, the use of Aldox- or hydrogen peroxide-based storage fluids may reduce the risk of <em>Fusarium</em> keratitis, while polyhexanide-based agents largely lack efficacy against <em>Fusarium</em>.</p></div>\",\"PeriodicalId\":50312,\"journal\":{\"name\":\"International Journal of Medical Microbiology\",\"volume\":\"314 \",\"pages\":\"Article 151602\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-01-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1438422124000067/pdfft?md5=e95ff8ddac5e11989d252e6f9ed43c19&pid=1-s2.0-S1438422124000067-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Medical Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1438422124000067\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1438422124000067","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Polyhexanide based contact lens storage fluids frequently exhibit insufficient antifungal activity against Fusarium species
Purpose
Fusarium keratitis is a severe infection of the anterior eye, frequently leading to keratoplasty or surgical removal of the affected eye. A major risk factor for infection is the use of contact lenses. Inadequate hygiene precautions and mold-growth permissive storage fluids are important risk factors for fungal keratitis. The aim of this study was to comparatively analyze contact lens storage fluids disinfection efficacy against Fusarium species.
Methods
Eleven commercially available storage fluids were tested. The storage fluids were classified according to their active ingredients myristamidopropyldimethylamine (Aldox), polyhexanide and hydrogen peroxide. Efficacy was tested against isolates belonging to the Fusarium solani and Fusarium oxysporum species complexes as the most common agents of mould keratitis. Tests were carried out based on DIN EN ISO 14729.
Results
All Aldox and hydrogen peroxide (H2O2) based fluids were effective against Fusarium spp., while the majority of polyhexanide based storage fluids showed only limited or no antifungal effects. Efficacy of polyhexanide could be restored by the addition of the pH-regulating agent tromethamine - an additive component in one commercially available product.
Conclusions
In summary, the use of Aldox- or hydrogen peroxide-based storage fluids may reduce the risk of Fusarium keratitis, while polyhexanide-based agents largely lack efficacy against Fusarium.
期刊介绍：
Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.
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