大脑导水管振荡流动的体外实验研究

IF 2.5 3区 工程技术 Q2 MECHANICS
S. Sincomb , F. Moral-Pulido , O. Campos , C. Martínez-Bazán , V. Haughton , A.L. Sánchez
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引用次数: 0

摘要

这项体外研究旨在阐明脑脊液(CSF)在脑导水管(连接第三脑室和第四脑室的狭窄管道)中的振荡流动与相应的脑室间压差之间的关系。在设计一个解剖学上正确的导水管流动缩放模型时采用了尺寸分析法,通过调整流动频率和工作流体的特性来保持物理相似性。在参数范围内测量了与给定振荡流速相对应的导水管时变压力差,该参数范围涵盖了健康人常见的流动条件。时间平均压力波动和跨导水管压力差与流速之间的相位滞后都与参数相关,两者都具有临床意义。通过与之前推导出的计算模型的预测结果进行比较,对结果进行了验证。这项研究中的参数量化能够推导出跨导管压力和每搏量之间关系的简单公式。这种关系有助于根据无创磁共振法测量导水管流量来量化跨导管压力差,以研究 CSF 相关疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct

An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct

An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct

This in vitro study aims at clarifying the relation between the oscillatory flow of cerebrospinal fluid (CSF) in the cerebral aqueduct, a narrow conduit connecting the third and fourth ventricles, and the corresponding interventricular pressure difference. Dimensional analysis is used in designing an anatomically correct scaled model of the aqueduct flow, with physical similarity maintained by adjusting the flow frequency and the properties of the working fluid. The time-varying pressure difference across the aqueduct corresponding to a given oscillatory flow rate is measured in parametric ranges covering the range of flow conditions commonly encountered in healthy subjects. Parametric dependences are delineated for the time-averaged pressure fluctuations and for the phase lag between the transaqueductal pressure difference and the flow rate, both having clinical relevance. The results are validated through comparisons with predictions obtained with a previously derived computational model. The parametric quantification in this study enables the derivation of a simple formula for the relation between the transaqueductal pressure and the stroke volume. This relationship can be useful in the quantification of transmantle pressure differences based on non-invasive magnetic-resonance-velocimetry measurements of aqueduct flow for investigation of CSF-related disorders.

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来源期刊
CiteScore
5.90
自引率
3.80%
发文量
127
审稿时长
58 days
期刊介绍: The European Journal of Mechanics - B/Fluids publishes papers in all fields of fluid mechanics. Although investigations in well-established areas are within the scope of the journal, recent developments and innovative ideas are particularly welcome. Theoretical, computational and experimental papers are equally welcome. Mathematical methods, be they deterministic or stochastic, analytical or numerical, will be accepted provided they serve to clarify some identifiable problems in fluid mechanics, and provided the significance of results is explained. Similarly, experimental papers must add physical insight in to the understanding of fluid mechanics.
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