探索 FAPI PET/CT 在结直肠癌诊断和治疗管理中的疗效：文献综述和初步经验

IF 2.3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical and Translational Imaging Pub Date : 2024-01-24 DOI:10.1007/s40336-023-00609-w

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引用次数: 0

摘要

摘要 FAPI PET/CT 是一种创新的医学成像技术，已成为针对成纤维细胞活化蛋白（FAP）的一种有前途的方法。这种新方法有许多优点，如增加肿瘤吸收和减少背景噪声。因此，FAPI PET/CT 图像显示出肿瘤信号与背景信号的良好比例，从而可以进行精确的肿瘤分期、特征描述和检测。鉴于 FAP 在结直肠癌（CRC）中的高表达，FAPI PET/CT 有可能彻底改变 CRC 的分期、再分期和监测，并加强治疗管理和改善患者预后。本综述旨在详细概述 FAPI PET/CT 目前在 CRC 中的应用，同时提出未来的研究方向，特别是与标准 FDG PET 成像模式的比较。

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Exploring the efficacy of FAPI PET/CT in the diagnosis and treatment management of colorectal cancer: a comprehensive literature review and initial experience

Abstract

FAPI PET/CT, an innovative medical imaging technique, has emerged as a promising method to target fibroblast activation protein (FAP). This novel approach offers numerous benefits, such as increased tumor absorption and reduced background noise. As a result, FAPI PET/CT images demonstrate a favorable ratio of tumor signal to background, allowing for precise tumor staging, characterization, and detection. Given the heightened expression of FAP in colorectal cancer (CRC), FAPI PET/CT has the potential to revolutionize CRC staging, restaging, and monitoring, as well as enhance treatment management and improve patient prognosis. This comprehensive review aims to provide a detailed overview of the current applications of FAPI PET/CT in CRC, while also proposing future research directions, specifically in comparison to the standard FDG PET imaging modality.

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来源期刊

Clinical and Translational Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

3.60

自引率

4.80%

发文量

期刊介绍： Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.