中风后大脑生物标记物变化的傅立叶变换红外成像概念和方法综述。

IF 2.8 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Rhiannon E. Boseley, Nicole J. Sylvain, Lissa Peeling, Michael E. Kelly, M. Jake Pushie
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引用次数: 0

摘要

脑卒中是神经科学和公共卫生研究的核心领域,因为它在全球范围内导致死亡和残疾。中风(包括缺血性和出血性事件)的病理生理学错综复杂,涉及到向大脑输送氧气和营养物质的中断。中枢神经系统这些关键过程的中断会导致新陈代谢失调和细胞死亡。傅立叶变换红外(FTIR)光谱可同时测量脑组织内的总蛋白质和脂质含量,以及一些传统技术无法观察到的关键生物标记物。傅立叶变换红外成像技术可将分析前未经化学处理的组织中的这些信息可视化,从而保留其空间分布和原位化学信息。在此,我们将综述用于研究中风后大脑生物标记反应的傅立叶变换红外成像方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A review of concepts and methods for FTIR imaging of biomarker changes in the post-stroke brain

A review of concepts and methods for FTIR imaging of biomarker changes in the post-stroke brain

A review of concepts and methods for FTIR imaging of biomarker changes in the post-stroke brain

Stroke represents a core area of study in neurosciences and public health due to its global contribution toward mortality and disability. The intricate pathophysiology of stroke, including ischemic and hemorrhagic events, involves the interruption in oxygen and nutrient delivery to the brain. Disruption of these crucial processes in the central nervous system leads to metabolic dysregulation and cell death. Fourier transform infrared (FTIR) spectroscopy can simultaneously measure total protein and lipid content along with a number of key biomarkers within brain tissue that cannot be observed using conventional techniques. FTIR imaging provides the opportunity to visualize this information in tissue which has not been chemically treated prior to analysis, thus retaining the spatial distribution and in situ chemical information. Here we present a review of FTIR imaging methods for investigating the biomarker responses in the post-stroke brain.

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来源期刊
Biochimica et biophysica acta. Biomembranes
Biochimica et biophysica acta. Biomembranes 生物-生化与分子生物学
CiteScore
8.20
自引率
5.90%
发文量
175
审稿时长
2.3 months
期刊介绍: BBA Biomembranes has its main focus on membrane structure, function and biomolecular organization, membrane proteins, receptors, channels and anchors, fluidity and composition, model membranes and liposomes, membrane surface studies and ligand interactions, transport studies, and membrane dynamics.
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