垂体功能减退的年轻成人停止生长激素治疗后骨骼肌的变化。

Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI:10.1111/j.1651-2227.1989.tb11244.x

O M Rutherford, D A Jones, J M Round, M A Preece

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引用次数: 34

摘要

对11例垂体功能减退患者停止使用人类生长激素(hGH)治疗后1年内骨骼肌力量和大小进行了测量。测量股四头肌和前臂屈肌最大自主等长强度和大小。在研究结束时，通过胰岛素耐量试验重新评估内分泌状况。11名受试者中有3名生长激素分泌正常，未被纳入分析。12个月时，股四头肌强度、大小和纤维面积分别为基线值的94.0 +/- 8.5%、94.5 +/- 6.3%和85.6 +/- 17.7%(平均+/- SD)。前臂屈肌力量和大小分别为对照组的101.4±7.9%和92±9.2%。尽管这些变化相对较小，但它们表明生长激素在成年人肌肉的维持中发挥了作用。

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Changes in skeletal muscle after discontinuation of growth hormone treatment in young adults with hypopituitarism.

Rutherford, O.M., Jones, D.A., Round, J.M. and Preece, M. (Department of Medicine, Rayne Institute, University College and Middlesex School of Medicine; and the Department of Growth and Development, Institute of Child Health, Great Ormond Street, London, UK). Changes in skeletal muscle after discontinuation of growth hormone treatment in young adults with hypopituitarism. Acta Paediatr Scand [Suppl] 356: 61, 1989.

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Acta paediatrica Scandinavica. Supplement

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