使用氯氮平与其他抗精神病药物的患者感染 COVID-19 后中性粒细胞绝对计数的变化。

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Seong Hoon Jeong, Mi Gyung Lee, Yong Sik Kim, In Won Chung
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引用次数: 0

摘要

据报道,服用氯氮平期间感染 COVID-19 的患者表现出明显的血液学反应。然而,由于缺乏对照组,很难将其归因于氯氮平。我们使用广义加法模型比较了两组重症精神病患者(49 名使用氯氮平的患者和 54 名使用其他抗精神病药物的患者)在感染 COVID-19 后 4 周内绝对中性粒细胞计数(ANC)的变化。尽管两组患者的 ANC 都出现了短暂下降,随后逐渐恢复的情况,但氯氮平组中的情况更为明显(P = 0.00025)。尽管如此,氯氮平组的 ANC 总体水平仍然较高。这些结果表明,氯氮平与 COVID-19 在血液动力学水平上可能存在相互作用。然而,这并不一定表明这种相互作用必然有害或危险。更令人担忧的是,一些使用其他抗精神病药物的患者表现出 ANC 下降,而且不易恢复。传统上,临床医生一直担心氯氮平患者感染 COVID-19 后血液副作用会恶化。然而,此次研究结果强调了对使用任何类型抗精神病药物治疗 SMIs 的患者进行血液学监测的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Change in absolute neutrophil count after COVID-19 infection in patients using clozapine versus other antipsychotics.

It was reported that patients who contracted COVID-19 while taking clozapine exhibited a distinct hematological response. However, the absence of control groups made it difficult to attribute it to clozapine. The changes in absolute neutrophil counts (ANCs) during the 4 weeks after COVID-19 infection were compared between the two groups of patients with severe mental illnesses (SMIs) (49 patients using clozapine and 54 using other antipsychotics) using generalized additive modeling. Although the pattern of a transient drop in ANC followed by gradual recovery could be demonstrated in both groups, it was more pronounced in the clozapine group ( P  = 0.00025). Nevertheless, overall ANC remained at a higher level in the clozapine group. The results suggested potential interaction between clozapine and COVID-19 at the level of hematological dynamics. However, it did not necessarily indicate that such interaction is inevitably harmful or dangerous. It was more of a concern that some patients using other antipsychotics exhibited decreased ANC, which did not easily recover. Traditionally, clinicians have been concerned about the worsening of hematological side effects in clozapine patients after COVID-19 infection. However, the obtained result highlighted the necessity of hematological monitoring in patients using any type of antipsychotics for SMIs.

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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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