{"title":"SOWAHB多态性影响中国汉族人群患甲状腺癌的风险。","authors":"Man Zhang, Jing Liang, Junhui Han, Wenjing Zhang, Panpan Wan, Leteng Yang, Xufeng Zang, Wanli Ren, Ling Zhang, Hao Dai, Yue Wu, Tianbo Jin","doi":"10.1080/14737159.2024.2305183","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to detect the correlation between <i>SOWAHB</i> polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.</p><p><strong>Methods: </strong>We genotyped <i>SOWAHB</i> variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between <i>SOWAHB</i> polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.</p><p><strong>Results: </strong>Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: <i>p</i> = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: <i>p</i> = 0.000, log-additive: <i>p</i> = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: <i>p</i> = 0.011, recessive: <i>p</i> = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: <i>p</i> = 0.030, dominant: <i>p</i> = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: <i>p</i> = 0.018, recessive: <i>p</i> = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: <i>p</i> = 0.001, dominant: <i>p</i> = 0.003).</p><p><strong>Conclusion: </strong><i>SOWAHB</i> SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"333-339"},"PeriodicalIF":3.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>SOWAHB</i> polymorphisms affect thyroid cancer risk in the Chinese Han population.\",\"authors\":\"Man Zhang, Jing Liang, Junhui Han, Wenjing Zhang, Panpan Wan, Leteng Yang, Xufeng Zang, Wanli Ren, Ling Zhang, Hao Dai, Yue Wu, Tianbo Jin\",\"doi\":\"10.1080/14737159.2024.2305183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to detect the correlation between <i>SOWAHB</i> polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.</p><p><strong>Methods: </strong>We genotyped <i>SOWAHB</i> variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between <i>SOWAHB</i> polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.</p><p><strong>Results: </strong>Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: <i>p</i> = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: <i>p</i> = 0.000, log-additive: <i>p</i> = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: <i>p</i> = 0.011, recessive: <i>p</i> = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: <i>p</i> = 0.030, dominant: <i>p</i> = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: <i>p</i> = 0.018, recessive: <i>p</i> = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: <i>p</i> = 0.001, dominant: <i>p</i> = 0.003).</p><p><strong>Conclusion: </strong><i>SOWAHB</i> SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.</p>\",\"PeriodicalId\":12113,\"journal\":{\"name\":\"Expert Review of Molecular Diagnostics\",\"volume\":\" \",\"pages\":\"333-339\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Molecular Diagnostics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14737159.2024.2305183\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2024.2305183","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
SOWAHB polymorphisms affect thyroid cancer risk in the Chinese Han population.
Objectives: This study aimed to detect the correlation between SOWAHB polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.
Methods: We genotyped SOWAHB variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between SOWAHB polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.
Results: Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: p = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: p = 0.000, log-additive: p = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: p = 0.011, recessive: p = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: p = 0.030, dominant: p = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: p = 0.018, recessive: p = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: p = 0.001, dominant: p = 0.003).
Conclusion: SOWAHB SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.
期刊介绍：
Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting.
Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy.
Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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