异翅类：治疗蛋白质的宝库

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-01-10 DOI:10.1163/23524588-00001062

M.R. Devi, A.S. Koijam, A. Brockmann, Y. Rajashekar

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引用次数: 0

摘要

杂翅目昆虫属于高度多样化的昆虫群体，包括陆生或水生昆虫，有以植物为食的昆虫、以血液为食的昆虫、捕食昆虫、食腐昆虫、食腐昆虫和食菌昆虫。这些昆虫被用于昆虫食疗和昆虫治疗。食用昆虫是重要的生物活性次生代谢物和生物活性肽的来源，具有治疗代谢紊乱的营养保健潜力。据报道，来自异翅昆虫的各种毒肽具有治疗特性，目前正在对其治疗各种疾病的效果进行持续研究。本综述列举了可食用的异翅目昆虫以及从异翅目昆虫中鉴定出的可用作替代药物的生物活性肽。文中简要介绍了异翅目昆虫的种类和食性。讨论了生物信息学在昆虫毒液转化方面的作用。此外，还讨论了基于治疗功能的蛋白质和肽的可能探索，以及使用现代生物信息学工具和科学验证过程进行高级研究的必要性。

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Heteropterans: a treasure trove of therapeutic proteins

Heteroptera belongs to a group of highly diversified insect forms ranging from plant feeders, blood-feeders, predators, scavengers, detritivores, and fungivores with terrestrial or aquatic habitats. These insects have been used in entomophagy and entomotherapeutic practices. Edible insects are a source of essential bioactive secondary metabolites and bioactive peptides, having nutraceutical potential to deal with metabolic disorders. Various venomous peptides from heteropterans with therapeutic properties have been reported and are constantly being investigated for various medical conditions. This review enlists heteropteran edible insects and bioactive peptides identified from heteropterans for use as an alternative medicine. The heteropteran categories and feeding habits have been briefly outlined. The role of bioinformatics in putting up a translational aspect of insect venom has been discussed. Further, the possible exploration of therapeutic function-based proteins and peptides and the need for advanced studies using modern bioinformatics tools, and scientific validation processes are also discussed.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.