Michael J. Carter, S. Shrestha, P. O’Reilly, P. Gurung, M. Gurung, S. Thorson, R. Kandasamy, M. Voysey, Elizabeth O’Mahony, Sarah Kelly, I. Ansari, Ganesh Shah, P. Amatya, Irina Tcherniaeva, Guy Berbers, David R. Murdoch, Andrew J. Pollard, S. Shrestha, Dominic F. Kelly
{"title":"评估针对肺炎球菌囊多糖的急性期和恢复期抗体浓度，以诊断社区获得性肺炎患儿是否感染了肺炎球菌","authors":"Michael J. Carter, S. Shrestha, P. O’Reilly, P. Gurung, M. Gurung, S. Thorson, R. Kandasamy, M. Voysey, Elizabeth O’Mahony, Sarah Kelly, I. Ansari, Ganesh Shah, P. Amatya, Irina Tcherniaeva, Guy Berbers, David R. Murdoch, Andrew J. Pollard, S. Shrestha, Dominic F. Kelly","doi":"10.1097/INF.0000000000004185","DOIUrl":null,"url":null,"abstract":"We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"32 21","pages":"e67 - e70"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia\",\"authors\":\"Michael J. Carter, S. Shrestha, P. O’Reilly, P. Gurung, M. Gurung, S. Thorson, R. Kandasamy, M. Voysey, Elizabeth O’Mahony, Sarah Kelly, I. Ansari, Ganesh Shah, P. Amatya, Irina Tcherniaeva, Guy Berbers, David R. Murdoch, Andrew J. Pollard, S. Shrestha, Dominic F. Kelly\",\"doi\":\"10.1097/INF.0000000000004185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.\",\"PeriodicalId\":501652,\"journal\":{\"name\":\"The Pediatric Infectious Disease Journal\",\"volume\":\"32 21\",\"pages\":\"e67 - e70\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Pediatric Infectious Disease Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/INF.0000000000004185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Pediatric Infectious Disease Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/INF.0000000000004185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia
We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.
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