Reticulated platelets and coronary slow flow: a study in stable coronary artery disease

Abstract Objectives The Coronary Slow Flow (CSF) phenomenon remains a clinical enigma, characterized by delayed opacification of coronary vessels despite angiographically normal or nearly normal arteries. This cross-sectional study explores the potential relationship between reticulated platelets (RPs) and CSF in stable coronary artery disease patients. Methods A total of 200 participants, meeting specific inclusion and exclusion criteria, underwent coronary angiography. Reticulated platelet levels were measured using Sysmex series hematology analyzers. Demographic data, laboratory parameters, and coronary flow velocities were assessed. Results The study comprised 100 individuals with CSF and 100 with normal coronary anatomy. The CSF group exhibited higher rates of diabetes (35 vs. 22 %, p=0.017) and smoking (62 vs. 45 %, p=0.021). Reticulated platelet rates were elevated in the CSF group. However, statistical significance was not reached (p=0.105). Conclusions This study provides insights into the interplay between reticulated platelets and the CSF phenomenon in stable coronary artery disease. Although reticulated platelet levels did not emerge as a major predictor for CSF in this stable phase, the findings contribute to ongoing efforts to understand the multifaceted mechanisms underlying CSF.