克服含氮化合物的 NMR 线宽：简单的解决方案

IF 1.9 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Magnetic Resonance in Chemistry Pub Date : 2024-01-23 DOI:10.1002/mrc.5432

Junhe Ma, Qingmei Ye, Rebecca A. Green, John Gurak, Sloan Ayers, Yande Huang, Scott A. Miller

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引用次数: 0

摘要

这项研究为阐明发生异构化的含氮化合物的结构提出了一个直接的解决方案。当发生与异构化相关的谱线展宽时，无论是原向同分异构还是键旋转，都会对结构阐释构成重大障碍。通过添加酸，我们展示了克服这一问题的简单方法，并有效地锐化了酸稳定原向同分异构体以及含有吗啉或哌嗪环的构象异构体的 NMR 信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Overcoming NMR line broadening of nitrogen containing compounds: A simple solution

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Overcoming NMR line broadening of nitrogen containing compounds: A simple solution

This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring.

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来源期刊

Magnetic Resonance in Chemistry 化学-光谱学

CiteScore

4.70

自引率

10.00%

发文量

审稿时长

1 months

期刊介绍： MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.