阻力训练和有氧训练可增加多囊卵巢综合征妇女的全基因组 DNA 甲基化。

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Epigenetics Pub Date : 2024-12-01 Epub Date: 2024-01-21 DOI:10.1080/15592294.2024.2305082
Cristiana Libardi Miranda Furtado, Megan Hansen, Gislaine Satyko Kogure, Victor Barbosa Ribeiro, Nathanael Taylor, Murilo Racy Soares, Rui Alberto Ferriani, Kenneth Ivan Aston, Timothy Jenkins, Rosana Maria Dos Reis
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引用次数: 0

摘要

体育锻炼是治疗多囊卵巢综合症(PCOS)的一线疗法。阻力运动或有氧运动可改善多囊卵巢综合征的代谢并发症、生殖结果和生活质量。运动过程中的 DNA 甲基化重编程可能是这些变化背后的主要调节因素。我们试图评估患有多囊卵巢综合症的女性在进行有监督的阻力运动和有氧运动后全基因组 DNA 甲基化的变化。我们对 56 名多囊卵巢综合症女性进行了为期 16 周(周)、每周三次、每次 50 分钟至一小时的运动(阻力运动,30 人;有氧运动,26 人)。训练前后测量了人体测量指数以及激素和代谢参数。全基因组白细胞 DNA 甲基化由 Infinium Human MethylationEPIC 850K BeadChip 芯片(Illumina)进行分析。阻力运动和有氧运动都能改善多囊卵巢综合征患者的人体测量指数、代谢功能障碍和高雄激素症,但两种运动之间没有差异。阻力运动和有氧运动都增加了全基因组的DNA甲基化,但阻力运动改变了CpG岛背景(岛屿、海岸、搁置和公海)中的每个类别,而有氧运动则改变了CpG海岸和公海。使用严格的 FDR(大于 40),在阻力运动队列中观察到 6 个显著差异甲基化区域(DMR),在有氧运动队列中观察到 14 个 DRMs,所有这些区域都是高甲基化的。全基因组 DNA 甲基化的增加可能与抵抗运动和有氧运动后在多囊卵巢综合征中观察到的代谢和激素变化有关。由于哺乳动物基因组在全球范围内都存在高甲基化以防止基因组的不稳定性和老化,阻力运动和有氧运动可能会通过环境诱导的表观遗传变化促进健康和长寿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome.

Physical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes.

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来源期刊
Epigenetics
Epigenetics 生物-生化与分子生物学
CiteScore
6.80
自引率
2.70%
发文量
82
审稿时长
3-8 weeks
期刊介绍: Epigenetics publishes peer-reviewed original research and review articles that provide an unprecedented forum where epigenetic mechanisms and their role in diverse biological processes can be revealed, shared, and discussed. Epigenetics research studies heritable changes in gene expression caused by mechanisms others than the modification of the DNA sequence. Epigenetics therefore plays critical roles in a variety of biological systems, diseases, and disciplines. Topics of interest include (but are not limited to): DNA methylation Nucleosome positioning and modification Gene silencing Imprinting Nuclear reprogramming Chromatin remodeling Non-coding RNA Non-histone chromosomal elements Dosage compensation Nuclear organization Epigenetic therapy and diagnostics Nutrition and environmental epigenetics Cancer epigenetics Neuroepigenetics
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