欧洲多角棘球蚴的线粒体遗传多样性和系统发育关系

IF 3.7 2区 医学 Q1 PARASITOLOGY
Azzurra Santoro , Federica Santolamazza , Simone M. Cacciò , Giuseppe La Rosa , Daniela Antolová , Herbert Auer , Guna Bagrade , Petra Bandelj , Walter Basso , Relja Beck , Carlo V. Citterio , Rebecca K. Davidson , Gunita Deksne , Caroline F. Frey , Eva Fuglei , Walter Glawischnig , Bruno Gottstein , Jiří Harna , Heidi Huus Petersen , Jacek Karamon , Adriano Casulli
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引用次数: 0

摘要

多孔棘球蚴绦虫是肺泡棘球蚴病的病原体,这是北半球一种致命的人畜共患寄生虫病。红狐是该病的主要宿主,也可能是该病在欧洲地域性传播的主要驱动力。了解欧洲范围内多角孢子虫分离物之间的遗传关系是了解多角孢子虫传播特征的关键。因此,本研究旨在描述从 19 个欧洲国家的不同宿主物种中分离出的多角体圆线虫的遗传多样性。根据对 cob、atp6、nad2、nad1 和 cox1 线粒体基因完整核苷酸序列(4968 bp)的分析,推断出 43 个单倍型。四种单倍型占受检分离物的 62.56%(142/227),除挪威斯瓦尔巴特群岛外,每个受调查国家都发现了这四种单倍型中的一种。虽然斯瓦尔巴群岛的单倍型与其他国家的单倍型有明显不同,但欧洲大陆似乎以两个主要群组为主,分别以大多数西欧、中欧和东欧国家以及波罗的海国家和波兰东北部为代表。此外,在拉脱维亚和波兰东北部还发现了一个类似亚洲的单倍型。为了更好地阐明多角体圆线虫亚洲基因变异在欧洲的存在,并更全面地覆盖整个欧洲,还需要进一步研究,包括本研究未调查的流行地区的样本,特别是一些东欧国家的样本。此外,本研究还提出了一些历史原因,这些原因可能促成了欧洲多角孢子虫目前的遗传变异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe

Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe

Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe

The cestode Echinococcus multilocularis is the causative agent of alveolar echinococcosis, a fatal zoonotic parasitic disease of the northern hemisphere. Red foxes are the main reservoir hosts and, likely, the main drivers of the geographic spread of the disease in Europe. Knowledge of genetic relationships among E. multilocularis isolates at a European scale is key to understanding the dispersal characteristics of E. multilocularis. Hence, the present study aimed to describe the genetic diversity of E. multilocularis isolates obtained from different host species in 19 European countries. Based on the analysis of complete nucleotide sequences of the cob, atp6, nad2, nad1 and cox1 mitochondrial genes (4,968 bp), 43 haplotypes were inferred. Four haplotypes represented 62.56 % of the examined isolates (142/227), and one of these four haplotypes was found in each country investigated, except Svalbard, Norway. While the haplotypes from Svalbard were markedly different from all the others, mainland Europe appeared to be dominated by two main clusters, represented by most western, central and eastern European countries, and the Baltic countries and northeastern Poland, respectively. Moreover, one Asian-like haplotype was identified in Latvia and northeastern Poland. To better elucidate the presence of Asian genetic variants of E. multilocularis in Europe, and to obtain a more comprehensive Europe-wide coverage, further studies, including samples from endemic regions not investigated in the present study, especially some eastern European countries, are needed. Further, the present work proposes historical causes that may have contributed to shaping the current genetic variability of E. multilocularis in Europe.

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来源期刊
CiteScore
8.40
自引率
2.50%
发文量
76
审稿时长
23 days
期刊介绍: International Journal for Parasitology offers authors the option to sponsor nonsubscriber access to their articles on Elsevier electronic publishing platforms. For more information please view our Sponsored Articles page. The International Journal for Parasitology publishes the results of original research in all aspects of basic and applied parasitology, including all the fields covered by its Specialist Editors, and ranging from parasites and host-parasite relationships of intrinsic biological interest to those of social and economic importance in human and veterinary medicine and agriculture.
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