SIRT3 在癌症中的作用与环境有关。

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-02-01 Epub Date: 2024-01-19 DOI:10.1016/j.tips.2023.12.005

Jin Zhang, Jing Ye, Shiou Zhu, Bo Han, Bo Liu

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引用次数: 0

摘要

Sirtuin 3（SIRT3）是一种依赖于 NAD+ 的去乙酰化酶，在调节代谢重编程和调控细胞死亡以及塑造肿瘤表型方面发挥着关键作用。由于 SIRT3 在决定肿瘤类型特异性或肿瘤演变方向方面的关键作用，开发 SIRT3 的小分子调节剂（包括抑制剂和激活剂）备受关注。在这篇综述中，我们讨论了最近关于 SIRT3 致癌或抑瘤功能的研究，评估了 SIRT3 靶向药物发现的进展，并提出了设计用于癌症治疗的 SIRT3 小分子调节剂的潜在途径。

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Context-dependent role of SIRT3 in cancer.

Sirtuin 3 (SIRT3), an NAD⁺-dependent deacetylase, plays a key role in the modulation of metabolic reprogramming and regulation of cell death, as well as in shaping tumor phenotypes. Owing to its critical role in determining tumor-type specificity or the direction of tumor evolution, the development of small-molecule modulators of SIRT3, including inhibitors and activators, is of significant interest. In this review, we discuss recent studies on the oncogenic or tumor-suppressive functions of SIRT3, evaluate advances in SIRT3-targeted drug discovery, and present potential avenues for the design of small-molecule modulators of SIRT3 for cancer therapy.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.