性激素对腹腔镜胆囊切除术患者术后疼痛的影响

IF 1.1 4区 医学 Q3 SURGERY
Kezban Koraş Sözen, Haci Bolat, İnayet Güntürk
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引用次数: 0

摘要

目的:影响术后疼痛的因素有很多。本研究确定了腹腔镜胆囊切除术患者术前性激素水平对术后疼痛水平的影响:本研究共纳入 89 名符合研究纳入标准的患者。根据性别和绝经前后的时期将患者分为三组:男性患者(28 人)、绝经后女性患者(31 人)和周期正常的女性患者(30 人)。正常周期的女性也根据卵泡期和黄体期重新分组。数据收集采用描述性特征表、患者随访表和视觉模拟量表:手术前抽取的静脉血样本用于测量患者的雌二醇(EST)、睾酮(TES)和孕酮水平。男性患者的疼痛程度低于女性患者。男性患者的视觉模拟量表(Visual Analog Scale)评分与他们的睾酮(TES)水平成反比,并与之密切相关(P < 0.05)。然而,亚组分析表明,男性患者的EST水平起主要作用,而EST/TES比率在术后晚期起决定性作用。在女性患者中,EST/孕酮比率是绝经后疼痛程度的最大决定因素,而绝经前在月经周期的不同阶段则没有变化:结论:性激素可有效预测术后疼痛的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Sex Hormones on Postoperative Pain in Patients with Laparoscopic Cholecystectomy.

Objective: There are many factors that affect postoperative pain. This study determines the effect of preoperative sex hormone levels on postoperative pain levels in patients undergoing laparoscopic cholecystectomy.

Patients and methods: This study included a total of 89 patients who met the study inclusion criteria. The patients were divided into 3 groups based on their sex and pre and postmenopausal periods: male patients (n = 28), postmenopausal female patients (n = 31), and female patients with normal cycles (n = 30). Normal-cycle women were also regrouped based on their follicular and luteal phases. Data were collected using a descriptive characteristics form, a patient follow-up form, and the Visual Analog Scale.

Results: Venous blood samples taken from the patients before surgery were used to measure their levels of estradiol (EST), testosterone (TES), and progesterone levels. Male patients had lower pain levels than female patients. The male patients' Visual Analog Scale scores were inversely related and correlated strongly with their TES levels ( P < 0.05). However, subgroup analyses suggested that their EST level played a primary role in males and that the EST/TES ratio was determinant in the late postoperative period. In female patients, the EST/progesterone ratio was the most determining factor for the level of pain felt in the postmenopausal period, whereas there was no change in the premenopausal period at different stages of the menstrual cycle.

Conclusions: Sex hormones were found to be effective in predicting postoperative pain severity.

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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
103
审稿时长
3-8 weeks
期刊介绍: Surgical Laparoscopy Endoscopy & Percutaneous Techniques is a primary source for peer-reviewed, original articles on the newest techniques and applications in operative laparoscopy and endoscopy. Its Editorial Board includes many of the surgeons who pioneered the use of these revolutionary techniques. The journal provides complete, timely, accurate, practical coverage of laparoscopic and endoscopic techniques and procedures; current clinical and basic science research; preoperative and postoperative patient management; complications in laparoscopic and endoscopic surgery; and new developments in instrumentation and technology.
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