Julie D. White, Melyssa S. Minto, Caryn Willis, Bryan C. Quach, Shizhong Han, Ran Tao, Amy Deep-Soboslay, Lea Zillich, Shaunna L. Clark, Edwin J. C. G. van den Oord, Thomas M. Hyde, R. Dayne Mayfield, Bradley T. Webb, Eric O. Johnson, Joel E. Kleinman, Laura J. Bierut, Dana B. Hancock
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引用次数: 0
摘要
背景 酒精使用障碍（AUD）对公共健康有着深远的影响。然而，人们对 AUD 发生和发展的分子机制的了解仍然有限。在这里，我们研究了成瘾相关脑区（即伏隔核（NAc）和背外侧前额叶皮层（DLPFC））内和之间与 AUD 相关的 DNA 甲基化（DNAm）变化。
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex
Background Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying the development and progression of AUD remain limited. Here, we interrogate AUD-associated DNA methylation (DNAm) changes within and across addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC).
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