SIRT1 调节内质网应激相关器官损伤

IF 2.3 4区生物学 Q4 CELL BIOLOGY

Acta histochemica Pub Date : 2024-01-01 DOI:10.1016/j.acthis.2024.152134

He Hu , Weichao Xu , Yan Li , Zhicheng Wang , Siyue Wang , Yansheng Liu , Minan Bai , Yingying Lou , Qian Yang

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引用次数: 0

摘要

内质网（ER）应激在多种器官损伤的发病机制中起着关键作用。研究表明，过度的ER应激（ERS）会破坏细胞的稳态，造成细胞损伤和多种器官的生理功能障碍。近年来，Sirtuin1（SIRT1）已成为ERS的研究热点。越来越多的证据表明，SIRT1 通过多种机制在各种 ERS 引起的器官损伤中发挥着积极作用，包括抑制细胞凋亡和促进自噬。SIRT1 还能通过抑制 ERS 减轻肝、心、肺、肾和肠道损伤。我们讨论了 SIRT1 的可能机制，探索了疾病的潜在治疗靶点，为治疗 ERS 相关疾病提供了理论依据。

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SIRT1 regulates endoplasmic reticulum stress-related organ damage

Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several organ damages. Studies show that excessive ER stress (ERS) can destroy cellular homeostasis, causing cell damage and physiological dysfunction in various organs. In recent years, Sirtuin1 (SIRT1) has become a research hotspot on ERS. Increasing evidence suggests that SIRT1 plays a positive role in various ERS-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. SIRT1 can also alleviate liver, heart, lung, kidney, and intestinal damage by inhibiting ERS. We discuss the possible mechanism of SIRT1, explore potential therapeutic targets of diseases, and provide a theoretical basis for treating ERS-related diseases.

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来源期刊

Acta histochemica 生物-细胞生物学

CiteScore

4.60

自引率

4.00%

发文量

107

审稿时长

23 days

期刊介绍： Acta histochemica, a journal of structural biochemistry of cells and tissues, publishes original research articles, short communications, reviews, letters to the editor, meeting reports and abstracts of meetings. The aim of the journal is to provide a forum for the cytochemical and histochemical research community in the life sciences, including cell biology, biotechnology, neurobiology, immunobiology, pathology, pharmacology, botany, zoology and environmental and toxicological research. The journal focuses on new developments in cytochemistry and histochemistry and their applications. Manuscripts reporting on studies of living cells and tissues are particularly welcome. Understanding the complexity of cells and tissues, i.e. their biocomplexity and biodiversity, is a major goal of the journal and reports on this topic are especially encouraged. Original research articles, short communications and reviews that report on new developments in cytochemistry and histochemistry are welcomed, especially when molecular biology is combined with the use of advanced microscopical techniques including image analysis and cytometry. Letters to the editor should comment or interpret previously published articles in the journal to trigger scientific discussions. Meeting reports are considered to be very important publications in the journal because they are excellent opportunities to present state-of-the-art overviews of fields in research where the developments are fast and hard to follow. Authors of meeting reports should consult the editors before writing a report. The editorial policy of the editors and the editorial board is rapid publication. Once a manuscript is received by one of the editors, an editorial decision about acceptance, revision or rejection will be taken within a month. It is the aim of the publishers to have a manuscript published within three months after the manuscript has been accepted