表达 PNAd 的血管是 CD3+ T 细胞介导的皮肤疾病真皮层的特征。

IF 3.4 3区 医学 Q3 IMMUNOLOGY
Fatimah Mohammad Budair, Takashi Nomura, Masahiro Hirata, Kenji Kabashima
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引用次数: 0

摘要

T 细胞被招募到皮肤组织对不同皮肤病的炎症至关重要;然而,这些 T 细胞进入皮肤的机制仍不清楚。表达外周结节地址(PNAd)(一种 L 选择素配体)的高内皮静脉位于次级淋巴器官,负责增加 T 细胞流入淋巴组织。在炎症期间,它们也会出现在非淋巴组织中。然而,它们在不同常见皮肤炎症疾病中的存在及其与 T 细胞浸润的相关性仍不清楚。在此,我们通过研究 PNAd 表达血管在不同皮肤病中的存在及其与 T 细胞存在的相关性,探索了 T 细胞进入皮肤的机制。对 43 例不同疾病患者的皮肤切片进行免疫组化和免疫荧光染色,以检测真皮层中是否存在表达 PNAd 的血管。评估了这些患者真皮层中这些血管的百分比与 CD3+ T 细胞浸润的严重程度/等级的相关性。在不同炎症性疾病患者的皮肤中普遍发现了表达 PNAd 的血管。这些血管在真皮中的高比例与 CD3+ T 细胞浸润的严重程度有关(P < 0.05)。此外,在表达 PNAd 的血管周围和血管腔内都发现了 CD3+ T 细胞。皮肤炎症性疾病中以 CD3+ T 细胞浸润为特征的 PNAd 表达血管可能是 T 细胞进入皮肤的关键入口。因此,选择性靶向这些血管可能有益于皮肤炎症性疾病的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PNAd-expressing vessels characterize the dermis of CD3+ T-cell-mediated cutaneous diseases.

T-cell recruitment to skin tissues is essential for inflammation in different cutaneous diseases; however, the mechanisms by which these T cells access the skin remain unclear. High endothelial venules expressing peripheral node address in (PNAd), an L-selectin ligand, are located in secondary lymphoid organs and are responsible for increasing T-cell influx into the lymphoid tissues. They are also found in non-lymphoid tissues during inflammation. However, their presence in different common inflammatory cutaneous diseases and their correlation with T-cell infiltration remain unclear. Herein, we explored the mechanisms underlying the access of T cells to the skin by investigating the presence of PNAd-expressing vessels in different cutaneous diseases, and its correlation with T cells' presence. Skin sections of 43 patients with different diseases were subjected to immunohistochemical and immunofluorescence staining to examine the presence of PNAd-expressing vessels in the dermis. The correlation of the percentage of these vessels in the dermis of these patients with the severity/grade of CD3+ T-cell infiltration was assessed. PNAd-expressing vessels were commonly found in the skin of patients with different inflammatory diseases. A high percentage of these vessels in the dermis was associated with increased severity of CD3+ T-cell infiltration (P < 0.05). Additionally, CD3+ T cells were found both around the PNAd-expressing vessels and within the vessel lumen. PNAd-expressing vessels in cutaneous inflammatory diseases, characterized by CD3+ T-cell infiltration, could be a crucial entry point for T cells into the skin. Thus, selective targeting of these vessels could be beneficial in cutaneous inflammatory disease treatment.

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来源期刊
CiteScore
8.40
自引率
2.20%
发文量
101
审稿时长
3-8 weeks
期刊介绍: Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our understanding of the immunopathology of human disease and/or change clinical practice. The journal is focused on translational and clinical immunology and is among the foremost journals in this field, attracting high-quality papers from across the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through scientific studies to the treatment, prevention or diagnosis of human disease. Clinical immunology has evolved as a field to encompass the application of state-of-the-art technologies such as next-generation sequencing, metagenomics and high-dimensional phenotyping to understand mechanisms that govern the outcomes of clinical trials.
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