Jihong Qiu , Chi-Yin Choi , Gene Chi-Wai Man , Xin He , Mingqian Yu , Mingde Cao , Qianwen Wang , Jonathan Patrick Ng , Patrick Shu-Hang Yung , Michael Tim-Yun Ong
{"title":"血清维生素 D 不足与前十字韧带损伤患者的股四头肌神经肌肉功能有关：初步研究","authors":"Jihong Qiu , Chi-Yin Choi , Gene Chi-Wai Man , Xin He , Mingqian Yu , Mingde Cao , Qianwen Wang , Jonathan Patrick Ng , Patrick Shu-Hang Yung , Michael Tim-Yun Ong","doi":"10.1016/j.asmart.2023.11.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate the correlations of serum vitamin D insufficiency with quadriceps neuromuscular function in patients with anterior cruciate ligament (ACL) injury.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted. Eighteen patients with a primary, unilateral ACL injury who had insufficient serum vitamin D concentrations (<30 ng/ml) were recruited for the study. Bilateral quadriceps neuromuscular function, including maximal strength, the speed of rapid contraction, and inhibition, were measured on an isokinetic dynamometer with the hip and the knee joint flexion at 90° and 45°, respectively. Quadriceps strength was measured by maximal voluntary isometric contractions (MVIC); the speed of rapid contraction was quantified by the rate of torque development (RTD), which was divided into the early (RTD<sub>0-50</sub>) and the late phase (RTD<sub>100-200</sub>); quadriceps inhibition was quantified by the central activation ratio (CAR). Serum vitamin D concentration was quantitatively determined by serum 25(OH)D concentration measured by the 25(OH)D ELISA kit. The Spearman rank correlation analysis was used to examine the correlation between the vitamin D concentration and bilateral quadriceps MVIC, RTD<sub>0-50</sub>, RTD<sub>100-200</sub>, and CAR, respectively.</p></div><div><h3>Results</h3><p>The results of Spearman rank correlation analyses showed that the serum 25(OH)D concentration was significantly correlated with bilateral quadriceps MVIC (injured: r = 0.574, p = 0.013; uninjured: r = 0.650, p = 0.003) and RTD<sub>0-50</sub> (r = 0.651, p = 0.003), and CAR (r = 0.662, p = 0.003) on the uninjured limb. However, no significant correlations were found between the serum 25(OH)D concentration and the other outcomes.</p></div><div><h3>Conclusions</h3><p>The serum vitamin D concentration correlates with quadriceps neuromuscular function in patients with ACL injury who had vitamin D insufficiency.</p></div>","PeriodicalId":44283,"journal":{"name":"Asia-Pacific Journal of Sport Medicine Arthroscopy Rehabilitation and Technology","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214687323000237/pdfft?md5=7af039e2294f6249cbe0de8b9155db74&pid=1-s2.0-S2214687323000237-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Serum vitamin D insufficiency is correlated with quadriceps neuromuscular functions in patients with anterior cruciate ligament injury: A preliminary study\",\"authors\":\"Jihong Qiu , Chi-Yin Choi , Gene Chi-Wai Man , Xin He , Mingqian Yu , Mingde Cao , Qianwen Wang , Jonathan Patrick Ng , Patrick Shu-Hang Yung , Michael Tim-Yun Ong\",\"doi\":\"10.1016/j.asmart.2023.11.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>This study aimed to investigate the correlations of serum vitamin D insufficiency with quadriceps neuromuscular function in patients with anterior cruciate ligament (ACL) injury.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted. Eighteen patients with a primary, unilateral ACL injury who had insufficient serum vitamin D concentrations (<30 ng/ml) were recruited for the study. Bilateral quadriceps neuromuscular function, including maximal strength, the speed of rapid contraction, and inhibition, were measured on an isokinetic dynamometer with the hip and the knee joint flexion at 90° and 45°, respectively. Quadriceps strength was measured by maximal voluntary isometric contractions (MVIC); the speed of rapid contraction was quantified by the rate of torque development (RTD), which was divided into the early (RTD<sub>0-50</sub>) and the late phase (RTD<sub>100-200</sub>); quadriceps inhibition was quantified by the central activation ratio (CAR). Serum vitamin D concentration was quantitatively determined by serum 25(OH)D concentration measured by the 25(OH)D ELISA kit. 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引用次数: 0
摘要
背景本研究旨在探讨前十字韧带（ACL）损伤患者血清维生素 D 不足与股四头肌神经肌肉功能的相关性。研究招募了 18 名血清维生素 D 浓度不足（30 ng/ml）的原发性单侧前十字韧带损伤患者。在髋关节和膝关节分别屈曲 90° 和 45° 的情况下，使用等动测力计测量双侧股四头肌的神经肌肉功能，包括最大力量、快速收缩速度和抑制作用。股四头肌力量通过最大自主等长收缩（MVIC）进行测量；快速收缩速度通过扭矩发展速度（RTD）进行量化，分为早期阶段（RTD0-50）和晚期阶段（RTD100-200）；股四头肌抑制通过中心激活比（CAR）进行量化。血清维生素 D 浓度通过 25(OH)D 酶联免疫吸附试剂盒测定的血清 25(OH)D 浓度进行定量测定。采用斯皮尔曼秩相关分析分别检验维生素 D 浓度与双侧股四头肌 MVIC、RTD0-50、RTD100-200 和 CAR 之间的相关性。结果Spearman等级相关分析结果显示，血清25（OH）D浓度与未受伤肢体的双侧股四头肌MVIC（受伤：r = 0.574，p = 0.013；未受伤：r = 0.650，p = 0.003）和RTD0-50（r = 0.651，p = 0.003）以及CAR（r = 0.662，p = 0.003）显著相关。结论前交叉韧带损伤患者维生素 D 不足时，血清维生素 D 浓度与股四头肌神经肌肉功能相关。
Serum vitamin D insufficiency is correlated with quadriceps neuromuscular functions in patients with anterior cruciate ligament injury: A preliminary study
Background
This study aimed to investigate the correlations of serum vitamin D insufficiency with quadriceps neuromuscular function in patients with anterior cruciate ligament (ACL) injury.
Methods
A cross-sectional study was conducted. Eighteen patients with a primary, unilateral ACL injury who had insufficient serum vitamin D concentrations (<30 ng/ml) were recruited for the study. Bilateral quadriceps neuromuscular function, including maximal strength, the speed of rapid contraction, and inhibition, were measured on an isokinetic dynamometer with the hip and the knee joint flexion at 90° and 45°, respectively. Quadriceps strength was measured by maximal voluntary isometric contractions (MVIC); the speed of rapid contraction was quantified by the rate of torque development (RTD), which was divided into the early (RTD0-50) and the late phase (RTD100-200); quadriceps inhibition was quantified by the central activation ratio (CAR). Serum vitamin D concentration was quantitatively determined by serum 25(OH)D concentration measured by the 25(OH)D ELISA kit. The Spearman rank correlation analysis was used to examine the correlation between the vitamin D concentration and bilateral quadriceps MVIC, RTD0-50, RTD100-200, and CAR, respectively.
Results
The results of Spearman rank correlation analyses showed that the serum 25(OH)D concentration was significantly correlated with bilateral quadriceps MVIC (injured: r = 0.574, p = 0.013; uninjured: r = 0.650, p = 0.003) and RTD0-50 (r = 0.651, p = 0.003), and CAR (r = 0.662, p = 0.003) on the uninjured limb. However, no significant correlations were found between the serum 25(OH)D concentration and the other outcomes.
Conclusions
The serum vitamin D concentration correlates with quadriceps neuromuscular function in patients with ACL injury who had vitamin D insufficiency.
期刊介绍：
The Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology (AP-SMART) is the official peer-reviewed, open access journal of the Asia-Pacific Knee, Arthroscopy and Sports Medicine Society (APKASS) and the Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine (JOSKAS). It is published quarterly, in January, April, July and October, by Elsevier. The mission of AP-SMART is to inspire clinicians, practitioners, scientists and engineers to work towards a common goal to improve quality of life in the international community. The Journal publishes original research, reviews, editorials, perspectives, and letters to the Editor. Multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines will be the trend in the coming decades. AP-SMART provides a platform for the exchange of new clinical and scientific information in the most precise and expeditious way to achieve timely dissemination of information and cross-fertilization of ideas.
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